Other intermediates Celecoxib Raw

CAS:169590-42-5

MF:C17H14F3N3O2S

MW:381.37

EINECS:685-962-5

Specification: 99% min Celecoxib Powder

Sample:Celecoxib Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Celecoxib Powder Usage and Synthesis.

Celecoxib and rofecoxib are two specific inhibitors of cyclooxygenase-2 (COX-2) commonly used in clinical practice, successfully developed by GDSearle & Pfizer in the United States, marketed and sold in 1999 under the trade name of Celebrex, Celebrex, which has significant analgesic and anti-inflammatory effects, with the lowest incidence of upper gastrointestinal ulcers and other complications.

Celecoxib is a non-steroidal anti-inflammatory drug, through the inhibition of cyclooxygenase-2 (COX-2) to block arachidonic acid synthesis of prostaglandins and play an anti-inflammatory and analgesic effect. It is clinically indicated for the treatment of acute and chronic osteoarthritis and rheumatoid arthritis.

Uses and functions of Celecoxib.

Used in the treatment of arthritis, with anti-inflammatory and analgesic effects, relieving the signs and symptoms of osteoarthritis and rheumatoid arthritis

For symptomatic treatment of osteoarthritis and rheumatoid arthritis.

Physiological Effect of Celecoxib.

Celecoxib has the anti-inflammatory and analgesic effects of NSAIDs. Due to its chemical structure, it binds to COX-2 and selectively inhibits COX-2. The phenyl group of celecoxib binds to the hydrophobic channel of COX-2, and the hydrophilic sulfonamide group forms a hydrogen chain with arginine at position 513 and histidine at position 90 in the "side pocket" of COX-2.

This product and COX-2120 position of the arginine close combination and play a role in inhibiting COX-2 on the conversion of arachidonic acid into the human body is not conducive to the role of prostaglandins, due to the COX-1 and COX-2 structure of the subtle differences, the drug can not enter the molecule of the COX-1, but also can not inhibit the conversion of arachidonic acid by the COX-1 to the role of the prostaglandins.

Therefore, it has good anti-inflammatory and analgesic, protects gastric mucosa, maintains renal blood flow, regulates platelet coagulation, and solves the digestive tract irritation effect of commonly used NSAIDs.

Adverse Reaction of Bulk Celecoxib Powder.

Less frequently, there are gastrointestinal reactions and minimal effects on renal function and platelets. Acute overdose may be associated with fatigue, drowsiness, nausea, vomiting, and epigastric pain, which may resolve with supportive therapy. Gastrointestinal bleeding may occur. Rarely hypertension, acute renal failure, respiratory depression and coma.