Levodopa raw materials Levodopa Powder

CAS:59-92-7

MF:C9H11NO4

MW:197.19

EINECS:200-445-2

Specification: 99% min Levodopa Powder

Sample:Levodopa Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Levodopa Powder Usage and Synthesis.

Levodopa is a precursor substance to dopamine, and is the common international name for the drug, with different manufacturers having different trade names when the drug is marketed. Oral levodopa tablets usually disintegrate and dissolve in the stomach, then drain to the duodenum, and then reach the small intestine, where it is absorbed into the bloodstream at the upper end of the small intestine, and a small portion of the levodopa can finally enter the brain through the blood-brain barrier, and be ingested by nigral neuronal cells or other neuronal cells, and then under the action of the enzyme dopa decarboxylase, a carboxyl group is removed, which turns into dopamine. Under the action of dopa decarboxylase, one of the carboxyl groups is removed and turned into dopamine, thus replenishing dopamine in the brain and reducing the symptoms of Parkinson's disease.

Levodopa has the ability to treat Parkinson's Disease and Parkinson's Syndrome; treat hepatic coma, improve central function, wake up patients and improve symptoms. Promotes sleep and reduces fat; increases bone density and reverses osteoporosis; increases muscle strength and enhances sexual performance.

Uses and functions of Levodopa.

Levodopa has the ability to treat Parkinson's Disease and Parkinson's Syndrome; treat hepatic coma, improve central function, wake up patients and improve symptoms. Promotes sleep and reduces fat; increases bone density and reverses osteoporosis; increases muscle strength and enhances sexual performance.

Levodopa is currently one of the effective drugs for the treatment of tremor paralysis, one of the precursors for the synthesis of norepinephrine, dopamine, etc. in the body, a catecholamine.

Levodopa can enter the brain through the blood-brain barrier, and is converted into dopamine by decarboxylation of dopa decarboxylase. However, the effect is slow and the side effects are large. The oral LD50 in rats is >4000mg/kg.

Effective drug for the treatment of tremor paralysis, mainly used in Parkinson's syndrome and so on.

Side Effect of Levodopa.

Possible side effects of levodopa include:

Gastrointestinal reactions: at therapeutic doses, nausea and loss of appetite occur in about 80% of early doses. This is due to direct stimulation of the gastrointestinal tract by DA and excitation of the emetic chemoreceptor area of the medulla oblongata.

It can be reduced by taking it with meals and slowing down the rate of increase. Or treat with domperidone (morpholine).

Cardiovascular reactions: early about 30% of patients with mild postural hypotension, continue to use the drug can be reduced. There are also reactions such as cardiac arrhythmia.

Product Method of  Bulk Levodopa Powder.

Dopa is contained in some legumes and is oxidatively polymerised by oxidative enzymes to produce melanin. The pods of some legumes turn black at maturity.

Melanins such as human and animal hair, squid's ink method, and watermelon's seed coat also belong to this type of melanin. Levodopa, an amino acid, can be extracted from quinoa (MucunasempervirensHemsl) seeds. The extraction method is as follows: quinoa beans were crushed and extracted with a mixture of 30% ethanol and 0.1% acetic acid at room temperature for three times, each time for 24 h. The extract was filtered to obtain the extract.

The extract was concentrated under reduced pressure (21.3kPa), precipitated crystals, left at 0-10 ℃ overnight, filtered, and levodopa crude. The crude product was dissolved with 1N hydrochloric acid, filtered with activated charcoal, and the filtrate was neutralised with a small amount of vitamin C with 2N ammonia to pH 3.5, and a large number of crystals were precipitated. it was allowed to stand at 0-10°C for 4h, and filtered.

Filter cake with a small amount of vitamin C distilled water washed twice, acetone dehydration once. 60-70 ℃ dry to get levodopa. In terms of bean powder, the yield is about 2%. Levodopa can also be obtained from the oxidation of L-tyrosine.

The tyrosine was dissolved in formic acid phosphoric acid, warmed to 40°C and held for 12h, and diluted with 20 times distilled water. The diluted solution is adsorbed with unreacted tyrosine through strongly acidic styrene-based cation exchange resin, and then the finished product is obtained through post-chip operation.