Iron Sucrose Raw material Iron Sucrose Powder

CAS:8047-67-4

MF:C18H24Fe2O24

MW:736.06

EINECS:232-464-7

Specification: 99% min Iron Sucrose Powder

Sample:Iron Sucrose Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: Brown to Dark Brown

Storage: Store at -20°C

Shelf Life: 2 Years

Test Method: HPLC

Iron Sucrose Powder Usage and Synthesis.

Iron sucrose is more suitable for oral iron intolerance or oral iron absorption is not good for the crowd, directly to the injection, can be effective for the human body to replenish iron, and need to pay attention to one point, that is, when we use the injection, the general situation of the infusion with saline with the infusion, understand the relevant amount of blood loss or need to replenish the amount of iron and so on, after the calculation is completed in the guidance of the doctor's advice to go to the use, the use of iron sucrose injections to control the speed of the injection, if the injection is too fast, may lead to the emergence of hypoglycaemic conditions.

Uses of Iron Sucrose.

It is clinically indicated for the treatment of iron deficiency anaemia that cannot be effectively relieved by oral iron supplements, such as those who need rapid iron supplementation for severe iron deficiency, those who have impaired absorption of oral iron supplements, and those who are intolerant to oral iron supplements.

Pharmacological Effect of Iron Sucrose.

Iron sucrose is a polynuclear iron(III) hydroxide with a core surface surrounded by a large number of non-covalently bound sucrose molecules, forming a complex with an average molecular weight of 43 kDa.

This macromolecular structure avoids being eliminated from the kidneys. This complex is structurally stable and releases iron ions under reasonable conditions.

ABSORPTION: A single intravenous dose containing 100 mg of the product results in the highest level after 10 min, averaging 538 μmol/L.

DISTRIBUTION: The volume of distribution in the central chamber is approximately 3L, and the steady-state volume of distribution is approximately 8L.

Metabolism and excretion: injected iron is rapidly eliminated from the plasma with a half-life of about 6 h. Iron clearance is less than 5% of the total clearance 4 h prior to injection of the product, and about 75% of the sucrose is excreted 24 h later.

Product Method of Bulk Iron Sucrose Powder.

(1) crystallisation: adjust the pH of sucrose solution to 1-4 with acetic acid, add iron salt solution to sucrose solution to form a mixture, adjust the pH of the mixture to 1-3 with Na2CO3 solution, stir, continue to add Na2CO3 solution to the mixture to the appearance of turbidity and the pH of the mixture is adjusted to 4-7, filter, and add water to get the discus solution;

(2) Complexation: heat the sucrose solution, add lye for alkalisation, add the discus solution to the alkalised sucrose solution, and leave it overnight to get the complexation solution;

(3) Refining: the complexing solution after standing overnight is filtered, and the filtrate is precipitated with 2-3 times of 95% ethanol and filtered, i.e. iron sucrose.