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Pharmaceutical Raw Materials Hydrocortisone Acetate Powder
Product Overview:
Hydrocortisone acetate (11β, 17α, 21-trihydroxypregna-4-ene-3,20-dione-21-acetate) belongs to the adrenocorticotropic hormone drugs, which have a variety of pharmacological effects such as anti-inflammatory, immunosuppressive, antitoxic, and anti-shock. The 11β-hydroxyl group in the structure of steroid compounds is a necessary group for anti-inflammatory drugs, and how to introduce the 11β-hydroxyl group in the preparation of hydrocortisone acetate is the key step of the whole process, and the existing processes mainly include microbial transformation method and chemical method.
Pharmaceutical Raw Materials Hydrocortisone Acetate Powder Attributes
CAS:50-03-3
MF:C23H32O6
MW:404.5
EINECS:200-004-4
Specification: 99% min Hydrocortisone Acetate Powder
Sample:Hydrocortisone Acetate Powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance: White to Off-White
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Pharmaceutical Raw Materials Hydrocortisone Acetate Powder Details
Hydrocortisone Acetate Powder Usage and Synthesis.
Hydrocortisone acetate is mainly used for the treatment of rheumatoid arthritis, rheumatic fever, gout, and bronchial asthma. The injection is used for tuberculous or purulent meningitis, tuberculous pleurisy, pyothorax, arthritis, tenosynovitis, tendon strain, sprain, nodular itchy rash, lichen planus, etc. Eye drops are used for all kinds of ophthalmia. Cream is used for allergic or seborrheic dermatitis, pruritus, etc.
Uses and functions of Hydrocortisone Acetate.
For allergic, non-infectious skin diseases and some proliferative skin disorders. Such as dermatitis, eczema, neurodermatitis, seborrheic dermatitis and pruritus.
Glucocorticoid drugs with anti-inflammatory, anti-allergic, antitoxin, anti-shock effect.
Pharmacological Effect of Hydrocortisone Acetate.
Hydrocortisone acetate is an adrenocorticotropic hormone drug, also known as cortisol acetate, white crystalline powder, odourless, bitter taste. Melting point 216～222℃, right-rotating optical. Slightly soluble in ethanol, ether, chloroform, acetone, insoluble in water.
Synthesised with 17α-hydroxyprogesterone as raw material. Hydrocortisone acetate has important physiological activities, such as anti-inflammatory, antiviral, anti-allergic, anti-shock, reduce inflammatory exudation, etc., commonly used in adrenocortical insufficiency and autoimmune diseases.
There are injections, tablets, ointments and eye drops. Adding a small amount of hydrocortisone acetate in some cosmetics can increase the anti-allergic efficacy and improve the degree of skin rejuvenation, but the long-term use of such substances can lead to hormone dependence of the skin.
China's cosmetic norms stipulate that hormonal substances should not be added to cosmetics.
Product Method of Bulk Hydrocortisone Acetate Powder.
Hydrocortisone and acetic anhydride esterified in pyridine
