Roxithromycin Raw Materials Roxithromycin Powder

CAS:80214-83-1

MF:C41H76N2O15

MW:837.05

EINECS:617-007-5

Specification​: 99% min Roxithromycin Powder

Sample:Roxithromycin Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White to Off-White

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Roxithromycin Powder Usage and Synthesis.

Roxithromycin is a semi-synthetic 14-membered ring macrolide antibiotic.

Its mechanism of action is similar to erythromycin, in vivo antibacterial effect is 1-4 times stronger than erythromycin, the role of gram-positive bacteria is slightly worse than erythromycin, the role of Legionella pneumophila is stronger than erythromycin, the anti-microbial effect of Chlamydia pneumoniae, Mycoplasma pneumoniae, ureido ureas, is similar to erythromycin or slightly stronger.

Roxithromycin is a semi-synthetic macrolide antibiotic. It can penetrate the bacterial cell membrane and achieve antibacterial effect by inhibiting bacterial protein synthesis.

Uses of Roxithromycin.

Macrolide antibiotics, for erythromycin derivatives, antibacterial spectrum and erythromycin similar, but the role of erythromycin 6 times stronger than erythromycin, high bioavailability.

It is used for respiratory tract infections, such as pneumonia, acute bronchitis, chronic bronchitis acute infection, atypical pneumonia, and genitourinary infections, skin and soft tissue infections, etc. It has good therapeutic effect and tolerance, and the adverse effects are smaller than erythromycin.

It is a new generation of macrolide antibiotics, mainly used for Gram-positive bacteria, anaerobes, chlamydia and mycoplasma. Its in vitro antibacterial effect is similar to that of erythromycin, and its in vivo effect is 1-4 times stronger than that of erythromycin.

Pharmacological Effect of Roxithromycin.

This product can cross the bacterial cell membrane, in close proximity to the donor ("P" position) and the 50S subunit of the bacterial ribosome into a reversible binding, blocking the transfer of ribonucleic acid binding to the "P" position, and at the same time also block the transfer of polypeptide chains from the acceptor ("A" position) to the "P" position, thus inhibiting the synthesis of bacterial proteins, thus playing an antibacterial role.

It also blocks the transfer of polypeptide chain from the acceptor site ("A" site) to the "P" site, thus inhibiting bacterial protein synthesis and thus acting as an antibacterial agent. Its characteristic is that it can enter macrophages, alveolar cells and neutrophils more quickly.

In vitro studies have confirmed that roxithromycin has a broad antibacterial spectrum, with antibacterial activity against a variety of streptococci (including Streptococcus A, B, C and Streptococcus pneumoniae, except G and enterococci), Streptococcus pneumoniae, Streptococcus aureus, Staphylococcus aureus (except MRSA), Staphylococcus epidermidis, Legionella pneumophila, Haemophilus ducreyi, Chlamydia trachomatis, Mycoplasma pneumoniae, and oral or vaginal anaerobes almost the same as erythromycin, and Cataplanham.

The antibacterial activity is almost the same as that of erythromycin, Catabranococcus is highly sensitive to Roxithromycin, and has inhibitory effect on Campylobacter, Bordetella pertussis, Haemophilus influenzae, Mycobacterium tuberculosis, Mycobacterium diphtheriae, and it has no antibacterial activity on other Gram-negative bacteria.

The in vivo antibacterial activity of this product is significantly stronger than that of erythromycin, and it is effective against Chlamydia, Mycoplasma, Ureaplasma urealyticum, Treponema pallidum and Legionella infections.

It has weaker effect on Helicobacter, Gonococcus, Meningococcus, B. pertussis and so on. Certain bacteria are cross-resistant to erythromycin and this product.

Production Method of Roxithromycin.

Erythromycin as raw material, and hydroxylamine hydrochloride in triethylamine and methanol reaction, the formation of oxime, and then and methoxyethoxymethyl chloride in acetone reaction, that is, to obtain roxithromycin