Raw materials Spironolactone Powder 52-01-7

CAS:52-01-7

MF:C24H32O4S

MW:416.58

EINECS:200-133-6

Specification: 99% min Spironolactone Powder

Sample: Spironolactone Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Spironolactone Powder Usage and Synthesis.

Spironolactone is a weak potassium-preserving diuretic, also known as Amphotericin and Spironolactone, with a chemical structure similar to aldosterone, it can compete with aldosterone for aldosterone receptors in the cell plasma of distal tubule and collecting ducts, affecting the binding of aldosterone and the receptor, thus impeding the synthesis of aldosterone-induced protein, and thus inhibiting the exchange of K+-Na+ and the reduction of potassium excretion, and playing the role of potassium preservation and diuresis.

There are currently two types of spironolactone on the market, one is spironolactone tablets and the other is Antibiotics Milk, whose composition and therapeutic principle are roughly the same, only the drug form is different.

Spironolactone has been invented for more than 40 years, and it is mainly used in conjunction with other drugs for the treatment of essential hypertension and oedematous diseases.

However, it is also used in medicine to treat androgenic alopecia because it reduces the amount of androgens in the body.

Spironolactone's anti-hormonal effect is weaker than that of finasteride, making it ideal for women suffering from hair loss.

Uses of Spironolactone.

Spironolactone is a competitive inhibitor of aldosterone, the drug itself is not active, the diuretic effect occurs as a result of competitive antagonism with endogenous aldosterone, and belongs to potassium-preserving diuretics.

①Oedematous diseases, combined with other diuretics to treat oedematous diseases such as congestive heart failure, cirrhosis ascites, renal oedema, etc. The purpose is to correct the secondary aldosterone secretion increase associated with the above diseases and to counteract the potassium excretion effect of other diuretics; it is also used in the treatment of idiopathic oedema.

② Hypertension, as an adjunctive therapeutic drug for hypertension.

③ Primary aldosteronism, spironolactone can be used in the diagnosis and treatment of this disease.

④ Prevention of hypokalaemia, combined with thiazide diuretics to enhance the diuretic effect and prevent hypokalaemia.

It is a synthetic 17-lactone steroid, a renal-competitive aldosterone antagonist, belonging to the class of potassium-preserving diuretics, mainly used in the treatment of liver disease, low-renin hypertension and hypokalaemia.

Active metabolite of lactone (amphotericin). Inhibits aldosterone biosynthesis. Blocker of the wowbaine effect.

A low potency diuretic with structural similarity to aldosterone and a competitive inhibitor of aldosterone.

Pharmacological Effect of Spironolactone.

The strength of the diuretic effect of spironolactone is related to the secretion of aldosterone in the body, the secretion of more than the role of strong, less secretion of the role of weak, no aldosterone secretion of the patient to take no diuretic effect.

Because the drug only acts on the distal tubule and collecting duct, no effect on other segments of the renal tubule, so the diuretic effect of the drug is weak, slow onset of action, maintenance time is long, is mainly used for stubborn oedema accompanied by aldosterone increase, such as cirrhosis ascites, congestive heart failure, nephrotic syndrome, etc., on congestive heart failure due to lack of sodium caused by the increase in secondary aldosterone patients with better efficacy, the diuretic effect of the single-use of the product tends to be poor! When used alone, the diuretic effect is often poor, often combined with hydrochlorothiazide or dihydroclonidine can enhance the efficacy.

It is also used in the treatment of primary aldosteronism and primary hypertension.

Product Method of Bulk Spironolactone Powder.

It can be synthesised from ethynylandrostenediol by format reaction, carboxylation, salt formation, hydrogenation, lactonisation, oxidation, elimination and addition.