Pharmaceutical Raw Materials Warfarin Sodium Powder

CAS:129-06-6

MF:C19H15O4.Na

MW:330.31

EINECS:204-929-4

Specification: 99% min Warfarin Sodium Powder

Sample:Warfarin Sodium Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White to Off-White

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Warfarin Sodium Powder Usage and Synthesis.

Warfarin sodium, the name of a western medicine. Common dosage forms include tablets. It is a medium-acting anticoagulant. Used for patients who need long-term continuous anticoagulation: treatment of thromboembolic disease, to prevent the formation and development of thrombosis; treatment of post-operative or traumatic venous thrombosis, and can be used as an adjunct to myocardial infarction; for patients who have had thromboembolic disease and those who are at risk of post-operative thrombotic complications, it can be given as a prophylactic drug.

Uses and functions of Warfarin Sodium.

This product is suitable for patients who need long-term continuous anticoagulation:

1、It can prevent the formation and development of thrombus, used in the treatment of thromboembolic disease.

2、Treatment of venous thrombosis after surgery or trauma line, and can be used as an adjunct to myocardial infarction.

3、It can be used as prophylactic medicine for patients who have had thromboembolic disease and those who are at risk of postoperative thrombotic complications.

Prevention and treatment of deep vein thrombosis and pulmonary embolism; prevention of thromboembolic complications after myocardial infarction (rate or body circulation embolism); prevention of atrial fibrillation, cardiac valve disease or prosthetic valve replacement caused by thromboembolic complications after surgery (rate or body circulation embolism).

Drug interactions of Warfarin Sodium.

1、Combined with chloral hydrate, the efficacy and toxicity of this product are enhanced, and should be used with caution in reduced dosage.

2, the absorption of vitamin K obstacle or synthesis decline also affect the anticoagulant effect of this product.

3, enhance the anticoagulant effect of this product are: aspirin, sodium salicylate, glucagon, quinidine, indomethacin, prednisone, quinine, diuretic acid, methylsulfonylurea, metronidazole, allopurinol, erythromycin, chloramphenicol, some aminoglycoside antibiotics, cephalosporins, pheniodarone, cimetidine, clofibrate, dexrazoxane, acetaminophen and so on.

4, to reduce the anticoagulant effect of the drug: phenytoin sodium, barbiturates, oral contraceptives, estrogen, cholestyramine, rifampicin, vitamin K, chlorthalidone, spironolactone, paracetamol, corticosteroids and so on.

5, can not be used in combination with this product: epinephrine hydrochloride, amikacin, vitamin B12, mesylate, pycnogenol, chlorpromazine hydrochloride, vancomycin hydrochloride and so on.

Note of  Bulk Warfarin Sodium Powder.

1、Strictly grasp the indications, in the absence of conditions of prothrombinogen determination, do not abuse this product.

2, individual differences are large, during the treatment period should closely observe the condition, and adjust the dosage according to the prothrombin time INR value.

Oral mucosa, nasal cavity, subcutaneous bleeding and fecal occult blood, haematuria, etc. should also be closely observed during the treatment period, unnecessary surgical operations should be avoided during the use of the drug, elective surgery should be discontinued for 7 days, emergency surgery needs to be corrected for the PTINR value of ≤ 1.6, to avoid overexertion and activities that are prone to injury.

3、If mild bleeding occurs, or prothrombin time has been significantly prolonged to more than 2.5 times of normal, the drug should be immediately reduced or discontinued.

Severe bleeding can be injected with vitamin K110-20mg to control bleeding, and if necessary, whole blood, plasma or plasminogen complex can be transfused.

4, because the product is an indirect action anticoagulant, long half-life, the efficacy of the drug can be stabilised only after 5-7 days of administration, therefore, the adequacy of the maintenance amount must be observed for 5-7 days before a conclusion is reached.