Mannitol Raw Materials Mannitol Powder

CAS:87-78-5

MF:C6H14O6

MW:182.17

EINECS:201-770-2

Specification: 99% min Mannitol Powder

Sample:Mannitol Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:White

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Mannitol Powder Usage and Synthesis.

1.Food

Mannitol is one of the commonly used sugar alcohols sugar substitute, commonly used in sugar-free chewing gum ingredients. Mannitol is the least absorbent sugar alcohols, can be used for food anti-sticking powder. China's health standards for the use of food additives GB2760-2007, can be used for sugar-free chewing gum, the maximum dosage of 200g / kg. JECFA confirmed that the ADI value of 0 ~ 50mg / (kg body weight - d).

US FDA stipulates the maximum use of mannitol in various types of food as follows: 98% for mints, 40% for soft candies, 5% for hard candies, 8% for preserves and ice creams, 5% for cough candies, 15% for jams and jellies, 31% for gummies, and 2.5% for other foods. In the U.S. Pharmacopoeia, natural medicine chapter, as well as in the Pharmacopoeia of the world, including the Food Chemistry Handbook (FEC) are listed in mannitol.

2.Medicine

Mannitol is used as injection infusion for lowering cerebral pressure, intraocular pressure and eliminating cerebral edema; used as diuretic; renal function and intestinal examination; mannitol infusion has certain efficacy in urinary and renal failure caused by edema and burns; and amino acid composite infusion.

Because of its good compression properties, it has become an excellent excipient for the pharmaceutical industry. In addition to mannitol as raw material for the synthesis of mannitol nitrogen mustard, mannitol bis(methanesulfonic acid) for antitumor drugs, suitable for chronic leukemia.

3.Chemical industry

Mannitol by esterification, etherification into a variety of resins and surface activators. Mannitol ester can be used as polyvinyl chloride plasticizer; and propylene oxide polymerization to generate polyether-based polyurethane rigid foam, can be used for insulation, sound insulation, moisture-proof materials.

Uses of Mannitol.

It is clinically used for the prevention of brain hernia, the treatment of brain tumor, head trauma, cerebral hypoxia and other causes of cerebral edema and increased cranial pressure, for the lowering of intracranial pressure safe and effective drug of choice.

Clinical reports show that the combined application of mannitol, sodium bicarbonate, dextrose 40 and vitamin E in the treatment of acute cerebral infarction has achieved remarkable results.

Because it can make the anterior chamber of the eye dehydrated, clinically also used in the treatment of glaucoma intraocular pressure elevation. As an osmotic diuretic can also be applied to prevent acute renal failure and acute oliguria induced by various reasons such as hypoxia, hemolysis and toxins.

It is also used clinically for the treatment of toxicity of barbiturates, salicylates or other drugs that are mainly excreted in the urine, promoting their elimination from the body through diuretic action.

It is used for cleansing the intestinal tract with quick-acting, safe and convenient, without sodium and water absorption problems, and can be used for gastrointestinal dialysis; its treatment of chronic renal failure should be accompanied by the appropriate amount of potassium, sodium, calcium, chlorine and bicarbonate; this drug can be used for the treatment of cirrhosis of the digestive tract hemorrhage and the prevention of hepatic coma; it can also be used for the treatment of intestinal obstruction and biliary colic, with an appropriate amount of potassium chloride, sodium chloride, orally or by injection into the gastric tube.

Pharmacological effect of Bulk Mannitol Powder.

(1)Tissue dehydration effect: injecting this product into the blood can increase the plasma osmotic pressure, resulting in the water in the tissues (including the eye, brain, cerebrospinal fluid, etc.) to enter the blood vessels, thus reducing tissue edema, lowering the intraocular pressure, intracranial pressure, and cerebrospinal fluid volume and its pressure.

Mannitol 1g can produce an osmotic concentration of 5.5mmol/L, injection of mannitol 100g can make 2L intracellular water transfer to extracellular, urinary sodium excretion of 50g.

(2) Diuretic effect:

(1) Mannitol increases blood volume and promotes the secretion of prostaglandin I2, which dilates the renal vasculature and increases renal blood flow including renal medullary blood flow. Glomerular entry arterioles dilated, glomerular capillary pressure increased, cortical glomerular filtration rate increased.

(ii) The product is rarely (<10%) reabsorbed by the renal tubules after filtration from the glomerulus, so it can increase the osmotic concentration of intra-tubular fluid and reduce the reabsorption of water and Na+, Cl-, K+, Ca2+, Mg2+ and other solutes in the renal tubules. After the application of large doses of mannitol, the water and Na+ through the proximal tubule only increased by 10%-20% and 4%-5%, respectively; while the water and Na+ reaching the distal tubule increased by 40% and 25%, suggesting that the reduction of reabsorption of water and Na+ by the Henschel's collaterals plays an important role in the diuretic effect of mannitol. This may be due to increased medullary blood flow and increased loss of urea and Na+ from the medulla, thereby disrupting the medullary osmotic pressure gradient difference.

(3) Detoxification: Due to the increase in glomerular and tubular fluid flow after mannitol infusion, when certain drugs and poisons are poisoned, the concentration of these substances in the renal tubules decreases, the toxicity to the kidneys decreases, and the excretion via the kidneys is accelerated.

Product Methods of Mannitol.