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Citicoline sodium raw Powder CAS 33818-15-4
Product Overview:
Cytarabine is a nucleic acid derivative, in 1956 Geiger found that cytarabine can recover brain damage in animal test; in 1957 Kennedy's research confirmed its vital importance in the synthesis of brain phospholipids, in 1961 Takeda Pharmaceutical Company of Japan developed and produced this product, and registered it in our country in 1988. It is currently the best-selling drug used in clinical treatment of brain diseases, and plays an important role in the synthesis of lecithin and improves brain function by promoting the synthesis of lecithin. Experiments have proved that cytarabine can enhance the level of norepinephrine and dopamine in the central nervous system, thus treating cerebrovascular disease, traumatic brain injury and cognitive disorders caused by various reasons, and there are no obvious side effects.
Citicoline sodium raw Powder CAS 33818-15-4 Attributes
CAS:33818-15-4
MF:C14H26N4O11P2.Na
MW:511.31
EINECS:251-689-1
Specification: 99% min Citicoline sodium
Sample:Citicoline sodium Powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance:White
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Citicoline sodium raw Powder CAS 33818-15-4 Details
Citicoline sodium Usage and Synthesis.
Cytarabine Sodium is a nucleoside derivative, mainly used to improve brain tissue metabolism, promote brain function recovery and awakening. It is mainly used for acute craniocerebral trauma and brain surgery-induced disorders of consciousness, but also for other functional and conscious disorders caused by acute injury to the central nervous system. In addition, cytarabine sodium is also used in the treatment of ischemic cerebrovascular disease and vascular dementia.
Uses of Citicoline sodium.
Coenzyme. For acute craniocerebral trauma and brain surgery after consciousness disorder. Acute craniocerebral trauma and brain surgery after consciousness disorders, for hemiplegia due to cerebral stroke can gradually restore the function of the limbs, but also can be used for other acute injury to the central nervous system caused by the function and consciousness disorders, but also used for ischemic cerebrovascular disease and vascular dementia .
Cytidine 5'-di-choline phosphate (CDP-choline), which supports lecithin synthesis, is produced by choline-phosphate cytidylyltransferase EC 2.7.7.15; used to study its role in neurorehabilitation.
In vitro effect of Citicoline sodium.
Citicoline is a major component of cell membrane phospholipids, a complex organic molecule composed of ribose, pyrophosphate, cytosine and choline.
Citicoline is water soluble and its oral bioavailability is greater than 90%. citicoline has no mitogenic or chemotactic effect on hCMEC/D3. However, it significantly enhances wound healing, sphere germination, and strongly induces the formation of endothelial tubular structures in the basement membrane matrix.
Citicoline induces the expression of phosphorylated ERK1/2. It protects hCMEC/D3 from cell injury/apoptosis.Citicoline induces vascular neovascularization and improves the survival of human brain microvascular endothelial cells through the p-ERK1/2 and IRS-1-related pathways.
Product Method of Citicoline sodium.
