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Nicotinamide Mononucleotide raw Powder
Product Overview:
Beta-nicotinamide mononucleotide is a product of the extracellular nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It improves glucose tolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression associated with oxidative stress, inflammatory responses, and circadian rhythms, in part through SIRT1 activation.
Nicotinamide Mononucleotide raw Powder Attributes
CAS:1094-61-7
MF:C11H15N2O8P
MW:334.22
EINECS:214-136-5
Specification: 99% min Nicotinamide Mononucleotide
Sample:Nicotinamide Mononucleotide Powder
Packaging:1kg/bag, 25kg/drum
Brand: Raw Materials
Appearance:White
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Nicotinamide Mononucleotide raw Powder Details
Nicotinamide Mononucleotide Usage and Synthesis.
Beta-nicotinamide mononucleotide is the precursor substance for the cofactor of longevity proteins in humans, NAD+.NAD+ is an important coenzyme of the tricarboxylic acid cycle, promoting the metabolism of sugars, fats, and amino acids, and participating in the synthesis of energy; NAD+ is also the sole substrate for coenzyme I-depleting enzymes (the sole substrate for the DNA-repairing enzyme PARP, for the longevity proteins Sirtuins, and for the cyclic ADP-ribose synthetase CD38/157 the sole substrate of CD38/157).
Uses of Nicotinamide Mononucleotide.
In mammals, β-nicotinamide mononucleotide is produced from nicotinamide (Nam) catalyzed by Nampt (a protease in vivo), and subsequently nicotinamide mononucleotide is catalyzed by nicotinamide mononucleotide adenylyltransferase to produce NAD+. Nicotinamide mononucleotides are a direct way to replenish NAD+.
It is by significantly enhancing the ability to repair intracellular DNA damage that nicotinamide mononucleotide ultimately achieves the reversal of aging. Nicotinamide mononucleotide is converted into nicotinamide adenine dinucleotide (NAD), which is essential for energy metabolism in the body.
In mouse tests, it has been shown that nicotinamide mononucleotide can activate a gene called acetylase in the body, thus exerting such effects as prolonging life and treating diabetes, etc. NAD is a substance that the human body can originally produce, and studies have confirmed that the amount of NAD in the body decreases with age.
Pharmacological effect of Nicotinamide Mononucleotide.
Product Method of Nicotinamide Mononucleotide.