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Natural dinogestrel raw Materials Powder dinogestrel
Product Overview:
dienoest is a kind of selective lutein drug newly listed in recent years. It can stabilize endometrial tissue by specific binding of ethylene nortestosterone and progesterone derivatives. Studies have found that tumor necrosis factor (TNF). And interleukin (IL-8) tend to be elevated in endometriosis patients.
Natural dinogestrel raw Materials Powder dinogestrel Attributes
CAS:65928-58-7
MF:C20H25NO2
MW:311.43
EINECS:639-448-2
Specification: 99% min dinogestrel Powder
Sample:dinogestrel Powder
Packaging:1kg/bag, 25kg/drum
Brand: raw Materials
Appearance:white
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Natural dinogestrel raw Materials Powder dinogestrel Details
dinogestrel Powder Usage and Synthesis.
Dinorgestrel is a hybrid progesterone that has the pharmacological advantages of both natural and synthetic progesterone. Dinorgestrel has a high progesterone activity and its oral semi-effective dose is 0.11mg/kg. The endocrine pharmacological properties of dinorgestrel are very desirable, because it only binds to the progesterone receptor, it has no estrogenic, anti-estrogenic, and androgenic activity, and its anti-gonadotropin effect (inhibiting the secretion of follicle-stimulating hormone and lutein hormone) is weak.
Uses of dinogestrel.
Dinorgestrel is a mixed progesterone with dual properties of 19-nortestosterone derivative and progesterone derivative. Therefore, it has the pharmacological advantages of both natural and synthetic progesterone and has high progesterone activity. A large randomized, double-blind, placebo-controlled clinical trial conducted by Harada et al. showed that after taking 2mg/d for 24 weeks, dinorgestrel was as effective as buserrelin in improving endometriosis related symptoms such as lower abdominal pain, lower back pain and dyspareunia, but the rate of adverse reactions such as vaginal bleeding and decreased bone density was significantly reduced and was better tolerated.
Pharmacological action of dinogestrel.
Dinorgestrel is a hybrid progesterone that has the pharmacological advantages of both natural and synthetic progesterone. Dinorgestrel has a high progesterone activity and its oral semi-effective dose is 0.11mg/kg. The endocrine pharmacological properties of dinorgestrel are very desirable, because it only binds to the progesterone receptor, it has no estrogenic, anti-estrogenic, and androgenic activity, and its anti-gonadotropin effect (inhibiting the secretion of follicle-stimulating hormone and lutein hormone) is weak.
Product Method of Bulk dinogestrel Powder.
