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Hrk supply Actinomycin D Raw materials powder
Product Overview:
Actinomycin D (Dactinomycin) is an organic compound with the chemical formula C62H86N12O16. It is a bright red crystalline powder, insoluble in petroleum ether, slightly soluble in water, soluble in methanol, ethanol and ethyl acetate, easily soluble in benzene, chloroform and acetone.
Actinomycin D can inhibit the synthesis of RNA and interfere with the transcription process of cells by acting on mRNA. After intravenous injection, it quickly disappears from the blood, within 24 hours, 12% to 25% is excreted by the kidney, and 50% to 90% is excreted by the bile. In combination with radiation, the sensitivity of the tumor to radiation can be increased.
Hrk supply Actinomycin D Raw materials powder Attributes
CAS:50-76-0
MF:C62H86N12O16
MW:1255.42
EINECS:200-063-6
Specification: 99% min Actinomycin D powder
Sample:Actinomycin D powder
Packaging:1kg/bag, 25kg/drum
Brand: Raw materials
Appearance:red
Storage: Store at -20°C
Shelf Life: 2 Years
Test Method: HPLC
Hrk supply Actinomycin D Raw materials powder Details
Actinomycin D powder Classification.
Hodgkin's disease (HD) : actinomycin D has outstanding efficacy in the treatment of Hodgkin's disease, especially in the control of fever.
Neuroblastoma: Similarly, actinomycin D has shown remarkable efficacy in the treatment of neuroblastoma.
Choriocarcinoma without metastasis: For the primary treatment of choriocarcinoma without metastasis, the cure rate of with actinomycin D alone is 90% to 100%, and the effect of is similar to that of MTX alone.
Testicular cancer: actinomycin D is also used in the treatment of testicular cancer, is often used in combination with other drugs.
Pediatric nephroblastoma (Wilms tumor) : When used in combination with radiotherapy, improves survival. is also effective for Youwen's sarcoma and rhabdomyosarcoma.
Uses of Actinomycin D.
Actinomycin D is extracted from a kind of actinomycetes isolated from soil after fermentation. In vitro studies have shown that actinomyctin D mainly acts on RNA, and at high concentrations, it affects RNA and DNA synthesis at the same time. The mechanism of action is that it is chimeric in the DNA double strand and binds to its guanine group, inhibits the DNA-dependent RNA polymerase activity, interferes with the transcription process of cells, and thus inhibits mRNA synthesis, that is, it can interfere with the transcription process of mRNA cells in human body, and has therapeutic effects on nerve and nephroblastoma, rhabdomyosarcoma, Hodgkin's disease and testicular tumor, etc. It can also be treated with actinomycin D.
Preparation of Actinomycin D.
Product Methods of Bulk Actinomycin D powder.
