Tacrolimus Raw Materials Powder Tacrolimus

CAS:

MF:C44H69NO12

MW:

EINECS:

Specification: 99% min Tacrolimus Powder

Sample:Tacrolimus

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:white

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Tacrolimus Powder Usage and Synthesis.

Tacrolimus, a fermented product isolated from Streptomyces, is a macrolide antibiotic and a potent immunosuppressant. It is a first-line drug used to prevent rejection after solid organ transplantation. At the same time, tacrolimus also has a good effect on bone marrow transplantation. In addition, tacrolimus also plays an active role in the treatment of autoimmune diseases such as atopic dermatitis, systemic lupus erythematosus, and autoimmune eye disease.

Uses and functions of Tacrolimus.

Tacrolimus, a fermented product isolated from Streptomyces, is a macrolide antibiotic and a potent immunosuppressant. It is a first-line drug used to prevent rejection after solid organ transplantation. At the same time, tacrolimus also has a good effect on bone marrow transplantation. In addition, tacrolimus also plays an active role in the treatment of autoimmune diseases such as atopic dermatitis, systemic lupus erythematosus, and autoimmune eye disease.

Tacrolimus is an immunosuppressant used primarily to prevent rejection after solid organ or bone marrow transplantation, or can be used in patients with autoimmune diseases.

Pharmacological action of Tacrolimus.

At the molecular level, tacrolimus apparently acts by binding to a cellular protein (FKBP12), which accumulates in the cell to produce its effect. The FKBP12-Tacrolimus complex specifically binds to and inhibits calcineulin, which inhibits calcium-dependent message pathways produced in T cells, thereby preventing the transcription of discontinuous lymphokine genes. This drug is highly immunosuppressive, and its activity has been confirmed in vitro and in vivo.

The drug inhibits the production of cytotoxic lymphocytes that are responsible for major graft rejection. It inhibits the activation of T cells and the proliferation of T helper cells dependent on B cells. It also inhibits the production of lymphatic factors such as interleukin-2, interleukin-3, and gamma-interferon, and the expression of interleukin-2 receptors. At the molecular level, the effect of the drug appears to be caused by binding to a cellular protein (FKBP), which also causes the compound to accumulate between cells. In vivo, the drug has been shown to be effective in liver and kidney transplantation.

Product method of Bulk Tacrolimus Powder.