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Promethazine Hydrochloride Raw Materials powder Promethazine Hcl
Product Overview:
Promethazine hydrochloride, also known as phenagine, is a commonly used phenothiazine antihistamine drug in clinical practice, although clinical reports of its adverse reactions are not rare, but because of its clear effect and low price, it is still widely used in grass-roots hospitals.
Promethazine hydrochloride is the earliest tricyclic antihistamine with phenothiazine structure, which has cough suppressive effect, can competitively block histamine H1 receptor and produce antihistamine effect, resist histamine-induced capillary dilatation, and reduce its permeability. Therefore, it can calm the cough caused by irritation of the trachea.
Promethazine Hydrochloride Raw Materials powder Promethazine Hcl Attributes
CAS:58-33-3
MF:C17H21ClN2S
MW:320.88
EINECS:200-375-2
Specification: 99% min Promethazine Hydrochloride powder
Sample:Promethazine Hydrochloride powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance:white
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Promethazine Hydrochloride Raw Materials powder Promethazine Hcl Details
Promethazine Hydrochloride powder Usage and Synthesis.
1, sedation: promethazine hydrochloride has a sedative effect, can relieve anxiety, tension and other emotions.
2, prevention and treatment of motion sickness: promethazine hydrochloride has a better prevention and treatment effect on motion sickness such as motion sickness, seasickness and airsickness.
3, anti-allergy: promethazine hydrochloride can be used to treat skin and mucous membrane allergy, allergic rhinitis, asthma, food allergy, skin scratches and other allergic diseases.
4, anti-vomiting: promethazine hydrochloride has anti-vomiting effect, can be used to relieve nausea, vomiting and other symptoms.
Uses and functions of Promethazine Hydrochloride.
Indication: It can competitively block the Hl receptor in the limbs of the group and produce antihistamine effect, which can resist the capillary dilatation caused by histamine, reduce its permeability, and relieve the wheezing caused by bronchial smooth muscle contraction. The effect is stronger and longer than that of diphenhydramine hydrochloride.
Pharmacological action of Promethazine Hydrochloride.
Promethazine is a phenothiazine antihistamine, and can also be used for nausea, motion sickness, and sedation and hypnosis.
1. Antihistamine effect: Competing with histamine released by tissues for H1 receptors, it can antagonize the contraction or contracture of the smooth muscle of the gastrointestinal tract, trachea, bronchus or bronchioles, and relieve the spasmodic and congested effect of histamine on the smooth muscle of the bronchus.
2. Antiemetic effect: It may be related to inhibiting the emetic chemical receptive area of the medulla oblongata.
3, anti-motion sickness: It may act on vestibular and vomiting centers and medulloid receptors in the midbrain through central anti-cholinergic activity, mainly blocking the excitation of cholinergic synaptic labyrinth impulse in vestibular nucleus.
4, sedative hypnotic effect: may indirectly reduce the irritability of the brain stem ascending reticular activation system.
Product method of Bulk Promethazine Hydrochloride.
