Hrk supply Neomycin sulfate Raw materials powder

CAS:1405-10-3

MF:C23H48N6O17S

MW:712.72

EINECS:215-773-1

Specification: 99% min Neomycin sulfate powder

Sample:Neomycin sulfate powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:white

Storage: Store at -20°C

Shelf Life: 2 Years

Test Method: HPLC

Neomycin sulfate powder of Usage and Synthesis.

Neomycin Sulfate is an aminoglycoside antibiotic. It has good antibacterial effect on Enterobacteriaceae such as Staphylococcus spp. (methicillin-sensitive strain), Corynebacterium spp., Escherichia coli, Klebsiella spp. and Aspergillus spp. It is poorly active against various groups of Streptococcus spp., Streptococcus pneumoniae and Enterococcus spp. Pseudomonas aeruginosa, anaerobes and other resistant to the product. Bacteria have partial or complete cross-resistance to streptomycin, neomycin and kanamycin, gentamicin. Neomycin has significant nephrotoxicity and ototoxicity when administered systemically, so it is limited to oral or topical application.

Uses of Neomycin sulfate.

Blocks voltage-sensitive Ca2+ channels without affecting the neuronal Na+/Ca2+ reverse transporter protein (antiporter). Binds to ribosomal 30S and 50S subunits causing protein miscoding; inhibits initiation and prolongation of protein synthesis. Antimicrobial spectrum:Gram-negative and positive bacteria. It can be used for the prevention and treatment of dysentery, diarrhoea and stunting caused by E. coli and Salmonella in pigs, chickens, cattle and other livestock and poultry. It can also be used as a treatment for enteritis in fish and shrimp in aquaculture. Broad-spectrum antibiotic, good for golden grape, diphtheria bacillus and anthrax bacillus.

In vitro studies of Neomycin sulfate.

Neomycin interacts preferentially with the nuclease-substrate complex and this interaction leads to a decrease in the cleavage rate by stabilising the ground state of the complex and destabilising the transition state of the cleavage step.Neomycin leads to a conformational change in the structure of the trans-activation region (TAR), which can be detected by circular dichroism spectroscopy.Neomycin acts as a non-competitive inhibitor of the Tat-TAR complex and increases the rate constant (Koff) of RNA and peptide dissociation. Neomycin acts as a non-competitive inhibitor that binds to the Tat-TAR complex and increases the rate constant (Koff) of RNA and peptide dissociation.Neomycin is the most potent aminoglycoside (groove complex) used to stabilise the triple-stranded helix of DNA.

Neomycin stabilises TAT, as well as mixed-base DNA triple helices, better than known DNA minor groove binders (which usually disrupt triple helices) and polyamines.Neomycin better stabilises TAT triple helices, but also stabilises CGC(+) triple helices.Neomycin concentration- and voltage-dependently induces a partial inhibition of the channels on the cytoplasmic and luminal surfaces. Neomycin has a greater affinity for the lumen than the cytoplasm: the dissociation constants (Kb(0)) at zero voltage are 210.2 nM and 589.7 nM, respectively.Neomycin also exhibits voltage-dependent relief of inhibition at potentials greater than 60 mV.

Product Methods of Bulk Neomycin sulfate powder.