Neomycin sulfate raw material Powder

CAS:1405-10-3

MF:C23H48N6O17S

MW:712.72

EINECS:215-773-1

Specification: 99% min Neomycin sulfate Powder

Sample:Neomycin sulfate Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:white

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Neomycin sulfate powder Usage and Synthesis.

Neomycin sulfate is an aminoglycoside antibiotic. The product has good antibacterial action against enterobacteriaceae bacteria such as Staphylococcus (methicillin-sensitive strains), Corynebacterium, Escherichia coli, Klebsiella, Proteus, etc., but poor activity against streptococcus, Streptococcus pneumoniae and Enterococcus in each group. Pseudomonas aeruginosa, anaerobic bacteria and other drug resistant to this product. The bacteria had partial or complete cross-resistance to streptomycin, neomycin, kanamycin and gentamicin. Systemic administration of neomycin has significant nephrotoxicity and ototoxicity, so it is limited to oral or topical use.

Uses of Neomycin sulfate.

Block voltage-sensitive Ca2+ channels without affecting the neuronal Na+/Ca2+ reverse transporter (antiporter). Chemicalbook binding to ribosome 30S and 50S subunits causes protein miscoding; Inhibit initiation and elongation during protein synthesis. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria. Broad-spectrum antibiotics have good effects on golden grape, diphtheria bacillus and anthrax bacillus. It is used to prevent and control dysentery, diarrhea and stunting caused by E. coli and salmonella in pigs, chickens, cattle and other livestock. It can also be used as a treatment of enteritis of fish and shrimp in aquatic products.

In vitro study of Neomycin sulfate.

Neomycin preferentially interacts with the ribozyme-substrate complex, and this interaction results in a reduced cleavage rate by stabilizing the complex's ground state and making the transition state of the cleavage step unstable. Neomycin leads to conformational changes in the structure of the trans-active region (TAR), which can be detected by circular dichroism. Neomycin acts as a non-competitive inhibitor that binds to the Tat-TAR complex and increases the rate constant (Koff) of RNA and peptide dissociation. Neomycin is the most effective aminoglycoside (furrow conjugate) for stabilizing the triple helix of DNA. Neomycin stabilizes TAT, as well as mixed base DNA triple helix, better than known DNA small groove binders (which usually break the triple helix) and polyamines. Neomycin stabilizes the TAT triple helix better, but also stabilizes the CGC (+) triple helix. Neomycin concentration and voltage dependence induced partial inhibition of cytoplasmic and luminal channels. The intracavity affinity of Neomycin is greater than that of the cytoplasm: the zero-voltage dissociation constants (Kb(0)) are 210.2nM and 589.7nM, respectively. Neomycin also showed inhibition of voltage-dependent response at potentials greater than 60mV.

Product Methods of Neomycin sulfate.