Medicine Antipsychotics raw Materials Powder Levosulpiride

CAS:23672-07-3

MF:C15H23N3O4S

MW:341.43

EINECS:233-599-4

Specification​: 99% min Levosulpiride Powder

Sample:Levosulpiride Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:White

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Levosulpiride Powder Usage and Synthesis.

Levosulpiride different dosage forms, different specifications of the dosage may vary, please read the specific drug instructions for use, or follow doctor's advice.

1、Schizophrenia: Adults take 100mg orally once, 2 times/day; Intramuscular injection once 100mg, 2 times/day.

2、Gastrointestinal disorders: 25mg orally once, 3 times/day.

3、Vomiting due to chemotherapy: Intravenous injection 1mg/kg once, 3 times/day.

4、Prevention of postoperative vomiting: single dose of 50-100mg intravenously before general anaesthesia.

Uses of Levosulpiride.

Levosulpiride Raw Materials is a very useful antigastric acid medication that plays an important role in the treatment of digestive disorders. Levosulpiride is available in a variety of types and preparation conditions, requiring the use of high purity raw materials and strict control of reaction conditions, purification and drying. As scientists continue to study Levosulpiride, we believe that it will play an even more important role in the future and make greater contributions to human health.

Pharmacological Effects of Levosulpiride.

Levosulpiride is a benzamide derivative, the left enantiomer of sulpiride, which is biologically active, blocking dopamine receptors and producing antipsychotic, antidepressant, antinausea and digestive effects. It is excitatory at low doses and inhibitory only at very high doses, with a lower D2/D3 affinity ratio. It is used at lower doses and has fewer adverse effects than the eliminators.

Product Method of Bulk Levosulpiride Powder.

Its preparation is the same as sulpiride, except that 2-aminomethyl-1-ethylpyrrolidine is chemically separated before reacting with 2-methoxy-5-aminosulfonyl benzoate to obtain an S-type reaction. At room temperature, a droplet of racemic 2-aminomethyl-1-ethylpyrrolidine is added to the aqueous solution of D-(-) -tartaric acid and stirred. Add anhydrous ethanol and leave overnight in the refrigerator. Filter solid, reflux with methanol, heat filtration, dry tartrate, yield 36.8%. The salt and sodium hydroxide aqueous solution are stirred at room temperature and chloroform is extracted. After drying, the extract was concentrated, distilled under pressure, and the fraction at 65℃/2.0kPa was collected to obtain (S)-(-)-2 aminomethyl-1-ethylpyrrolidine with a yield of 43.5%. The obtained S-type pyrrolidine and methyl 2-methoxy-5-aminosulfonyl benzoate were mixed in ethylene glycol at 120℃. The crude product was recrystallized with 95% ethanol to obtain Levosulpride with yield of 72.6%, melting point of 184 ~ 186℃, [α]D23-66.4°(C=0.5, dimethylformamide).