HRK Supply Ropivacaine HCl raw Materials powder

CAS:132112-35-7

MF:C17H26N2O.ClH.H2O

MW:328.88

EINECS:663-286-1

Specification​: 99% min Ropivacaine HCl Powder

Sample:Ropivacaine HCl Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:white

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Ropivacaine HCl Powder Usage and Synthesis.

Ropivacainehydrochloride is an effective sodiumchannel blocker. Ropivacaine induces nerve fiber pulse block by reversibly inhibiting sodium influx. Ropivacaine is also an inhibitor of K2P(two-pore potassium channel)TREK-1 with an IC50 value of 402.7μM on COS-7 cell membranes. Ropivacaine is used in animal models for local anesthesia and relief of neuropathic pain.

Uses of Ropivacaine HCl.

Ropivacaine hydrochloride is indicated for: surgical anesthesia ----- epidural anesthesia including cesarean section ----- subarachnoid anesthesia ----- regional block

Acute pain control ----- continuous epidural infusion or intermittent single medication, such as postoperative or vaginal labor analgesia ----- regional block

Pharmacological action of Ropivacaine HCl.

Ropivacaine, the first pure levo-body long-acting amide local anesthetic, has both anesthetic and analgesic effects, with large doses producing surgical anesthesia and small doses producing sensory block (analgesia) accompanied only by limited non-progressive motor nerve block. Addition of epinephrine did not change the blocking intensity and duration of ropivacaine.

Ropivacaine reversibly blocks impulse conduction along nerve fibers by blocking the flow of sodium ions into the membrane of nerve fibers. Local anesthetics may also have a similar effect on excitable cell membranes such as brain cells and cardiomyocytes, and if excess drugs enter the systemic circulation quickly, the central nervous system and cardiovascular system will show signs and symptoms of intoxication. Pregnant ewes did not show a greater sensitivity to ropivacaine than non-pregnant ewes.

Intravenous administration of ropivacaine was well tolerated in healthy volunteers, and clinical experience with this drug suggests a good safety range. Indirect cardiovascular effects (hypotension, bradycardia) may occur with epidural use, depending on the degree of parasympathetic block. At high concentrations, the inhibitory effect of bupivacaine on the composite action potential of Class A and Class C nerve fibers was 16% and 3% stronger than that of Ropivacaine hydrochloride, respectively, indicating that the sensory blocking effect of Ropivacaine hydrochloride and bupivacaine hydrochloride was similar, but the motor blocking effect of Ropivacaine hydrochloride was weak. At low concentration, ropivacaine hydrochloride mainly blocks sensory nerve fibers and has a light block on motor nerve fibers, that is, Ropivacaine hydrochloride has a high degree of separation of sensory and motor nerve blocks, and has a unique advantage for postoperative epidural analgesia.

Product method of Bulk Ropivacaine HCl Powder.