Artesunate raw Powder Artesunate

CAS:88495-63-0

MF:C19H28O8

MW:384.42

EINECS:618-170-5

Specification​: 99% min Artesunate

Sample:Artesunate Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:white

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Artesunate Usage and Synthesis.

Mechanism of action of artesunate artemisinin. It first acts on the plasmodium's food vesicles, superficial membranes and mitochondria. Secondly, the nuclear membrane and endoplasmic reticulum, in addition, also have a certain effect on the chromatin in the nucleus. Because this product first acts on the food membrane, thus blocking the nutritional intake. Causes the parasite to become amino acid hungry faster. Autophagy vacuoles form rapidly. And it keeps coming out of the body. It loses a lot of cytoplasm and dies. Artemisinin has a good killing effect against malaria both in vivo and in vitro. Artemisinin changes the structure of Plasmodium membrane by influencing the ultrastructure of Plasmodium erythroid phase. Due to the action of the food vesicle, the nutritional uptake of the malaria parasite is blocked, and when the malaria parasite loses a lot of cytoplasm and nutrients, and can not be supplemented, it soon dies. Its mode of action is through its internal peroxide (dioxygen) bridge, mediated by the free iron produced by the breakdown of hemoglobin, the production of unstable organic radicals and/or other electrophilic mediators, which then form covalent adjuncts with the protein of the malaria parasite and kill the malaria parasite.

Uses of Artesunate.

A semi-synthetic derivative of artemisinin that acts on the electron transport chain to produce local reactive oxygen species and cause depolarization of the mitochondrial membrane. It inhibits the production of TNF-induced pro-inflammatory cytokines by inhibiting the NF-κB and PI3 kinase /Akt signaling pathways in human rheumatoid arthritis fibroblast-like synoviocytes. Artesunate is a semi-synthetic artemisinin derivative that has been shown to be effective against parasites such as liver flukes and has also been shown to have cytotoxic effects on different types of tumor cell lines. It has a strong killing effect on plasmodium asexuality and can control malaria attack quickly.

Preparation of Artesunate.

Product method of Artesunate.