Ceftazidime raw Materials Powder

CAS:72558-82-8

MF:C22H22N6O7S2

MW:546.57

EINECS:276-715-9

Specification​: 99% min Ceftazidime Powder

Sample:Ceftazidime Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:White

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Ceftazidime Powder Usage and Synthesis.

Ceftazidime (containing sodium carbonate) is used for gram-negative bacteria caused by pneumonia and lower respiratory tract infection, abdominal and biliary tract infection, complex urinary tract infection and severe skin soft tissue infection. It is particularly suitable for infections of immunodeficient persons caused by multiple drug-resistant gram-bacteria, nosocomial infections, and central nervous system infections caused by gram-negative bacteria or Pseudomonas aeruginosa.

Uses of Ceftazidime.

Ceftazidme is the third generation of broad spectrum cephalosporin, stable to a variety of β-lactamase, gram positive bacteria and negative bacteria and anaerobic strains have strong bactericide effect, effective against pseudomonas aeruginosa, is the only one can replace aminoglycosides of cephalosporin antibiotics, so some people call it the fourth generation of cephalosporin antibiotics. Clinically, it is used for general serious infections caused by sensitive bacteria (such as sepsis, meningitis, bacteremia, etc.), respiratory tract infections (such as pneumonia, bronchitis, etc.), ear, nose and throat infections, skin and soft tissue infections, urinary tract infections, gastrointestinal, bile and abdominal infections, bone and joint infections, etc. Semi-synthetic broad spectrum cephalosporins are mainly used for respiratory system, urinary system, soft tissue system infection caused by sensitive bacteria.

Pharmacological action of Ceftazidime.

Ceftazidime (containing sodium carbonate) is the third generation cephalosporin, the enterobacteriaceae bacteria are highly sensitive to this product, its antibacterial activity is slightly worse than cefotaxime, has a good antibacterial effect on pseudomonas aeruginosa, and is the strongest activity among cephalosporins. Combined with tobramycin and amicacin showed obvious synergistic effect on multidrug-resistant Pseudomonas aeruginosa, and synergistic or additive effect on Pseudomonas aeruginosa and Escherichia coli with cefsulozidine, melocillin or piperacillin; Legionella pneumophila is sensitive to this product; It also has antibacterial effect on gram-positive bacteria and some anaerobic bacteria, and its antibacterial activity is lower than that of cefazolin and cefotaxime. It has no antibacterial effect on methicillin-resistant Staphylococcus, enterococcus, Campylobacter pylori or Clostridium difficile. It is suitable for the treatment of various serious gram-negative bacterial infections including Pseudomonas aeruginosa.

Product Method of Bulk Ceftazidime Powder.

It is best to use ceftioidime as a raw material, because ceftioidime has 3-pyridyl. After silanizing with trimethylsilyl chloride, and then reacting with phosphorus pentachloride at low temperature, adding low alcohols or diols to obtain amorphous solid, and then treating with acetonitrile containing hydrochloric acid or isopropyl alcohol and other suitable solvents to obtain pure crystalline compound (Ⅵ). Then it reacts with dichloromethane solution of compound (Ⅱ), the reaction solution is washed and steamed to remove dichloromethane, and dimethylformamide is added to obtain a pure compound (Ⅶ) containing 2.5 molecules of dimethylformamide, basically free of impurities. To compound (Ⅶ) of dimethylformamide solution, add formic acid and hydrochloric acid mixture for treatment, filter to remove precipitation, and then add acetone or methanol, you can get a very pure compound (Ⅷ). Dissolve the compound (Ⅷ) in water, adjust the pH value to the isoelectric point, the precipitation of ceftazidime pentahydrate crystal, high yield, pure and stable product. The side chain compound (I) used can be synthesized by the following method.