Heparin sodium raw powder

CAS:9041-08-1

MF:(C12H16NS2Na3)20

MW:/

EINECS:232-681-7

Specification​: 99% min Heparin sodium

Sample:Heparin sodium

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:white

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Heparin sodium Usage and Synthesis.

Heparin sodium

　　can delay or prevent blood clotting in and out of the body. Its mechanism of action is very complex, and it has influence on many links in the process of coagulation. Its effects are as follows: ① inhibit the formation and action of thromboplastin, thereby preventing prothrombin from becoming thrombin; (2) In higher concentrations, it can inhibit thrombin and other coagulation factors and prevent fibrinogen from becoming fibrin; ③ Can prevent platelet agglutination and destruction. In addition, the anticoagulant effect of heparin sodium is still related to the negatively charged sulfate in its molecules, and the positively charged alkaline substances such as protamine or toluidine blue can neutralize its negative charge, so it can inhibit its anticoagulant effect. Because heparin can activate and release lipoprotein esterase in the body, so that chylomicron triglyceride and low-density lipoprotein hydrolysis, so it also has the effect of lowering blood lipid.

Uses of Heparin sodium.

　　Heparin has a strong anticoagulant effect and is the first choice for preventing and treating thrombosis diseases such as deep vein thrombosis. Although it has been used in clinic for more than 60 years, there is no product that can completely replace it so far, so it is still one of the most important anticoagulant and antithrombotic biochemical drugs. It is widely used in medicine, for the treatment of acute myocardial infarction and pathogenic hepatitis, and the combination of ribonucleic acid can increase the efficacy of hepatitis B, combined with chemotherapy, is conducive to preventing thrombosis, and has a certain role in lowering blood lipids and improving human immune function. Low molecular weight heparin sodium has anticoagulant factor Xa activity. Pharmacodynamic studies have shown that low molecular weight heparin sodium has an inhibitory effect on the formation of in vivo and external thrombosis and arteriovenous thrombosis, but has little effect on coagulation and fibrinolysis system, and the possibility of bleeding is small when anti-thrombotic effect is produced. Common heparin is a mixture of glycosides that can delay or prevent blood clotting in and out of the body. Its anticoagulant mechanism is complex, and it has an effect on every link of coagulation.

In vitro study of Heparin sodium.

Product Method of Bulk Heparin sodium.

　　The intestinal mucosa of pigs, sheep, cattle and other animals is extracted and refined.