Fosfomycin Sodium Raw Materials Powder 26016-99-9

CAS:26016-99-9

MF: C3H8NaO4P

MW:162.06

EINECS:247-409-2

Specification: 99% min Fosfomycin Sodium Powder

Sample: Fosfomycin Sodium Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: Off-White to Pale Yellow

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Fosfomycin Sodium Powder Usage and Synthesis.

Fosfomycin sodium is mainly used clinically for the treatment of infections of the urinary tract, urinary system, skin and soft tissues, respiratory tract, intestinal tract and other parts of the body caused by sensitive gram-negative bacteria. It can also be used in combination with other antibiotics to treat severe infections caused by sensitive bacteria such as sepsis, lung, meningeal infections, peritonitis, uterine adnexitis, intrauterine infections, pelvic inflammatory disease, osteomyelitis and so on. It can also be used in combination with vancomycin to treat methicillin-resistant Staphylococcus aureus (MRSA) infections.

Uses and functions of Fosfomycin Sodium.

For the treatment of infections caused by Staphylococcus aureus, Escherichia coli, Proteus mirabilis and dysentery bacilli.

Mainly used for the treatment of acute and chronic intestinal diseases caused by staphylococcus, streptococcus, E. coli, salmonella and other gram-negative bacteria in chickens, ducks and pigs.

Treatment.

Pharmacological Effect of Fosfomycin Sodium.

1. Wide antimicrobial spectrum, high bioavailability, fast absorption, strong antimicrobial power, not affected by diet. It has killing effect on Gram-positive and negative bacteria, especially on Pseudomonas aeruginosa, Aspergillus, Salmonella and Staphylococcus and Escherichia coli which are resistant to various drugs can show excellent antibacterial activity. Used in animals, there is no drug resistance and cross-resistance, good clinical therapeutic effect.

2. Rapid bactericidal: this product is a rapid bactericide, its effect is already obvious after 1-2 hours. About 25% of Escherichia coli are killed 1 hour after contacting Phosphomycin (12.5μg/ml), while all of them die within 4-6 hours. Pseudomonas aeruginosa and Staphylococcus aureus were also killed completely in 4 and 8 hours respectively.

3. Low toxicity and side effects, low stimulation to the organism, no acute toxicity and adverse reactions, and will not aggravate the burden on the kidneys.

4. Low residual: the elimination time to reach the residual standard in muscle and organs is 48-72 hours.

Caveat of  Bulk Fosfomycin Sodium Powder.

1. This product is mainly used for pigs, chickens, fish; for other animals should be used under the guidance of veterinarians. 

2. Fosfomycin and β-lactams, aminoglycosides, macrolide esters have synergistic effects when used in combination, and can reduce or delay the occurrence of bacterial drug resistance