Pharmaceutical raw material antibiotics Tetracycline Hydrochloride Powder

CAS:64-75-5

MF:C22H25ClN2O8

MW:480.9

EINECS:200-593-8    

Specification: 99% min Tetracycline Hydrochloride Powder

Sample:Tetracycline Hydrochloride Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:Light Yellow Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Tetracycline Hydrochloride Powder Usage and Synthesis.

Tetracycline hydrochloride is a broad-spectrum antibiotic with bactericidal effect at high concentration. In addition to common Gram-positive, Gram-negative and anaerobic bacteria, most of the genera of Rickettsiae, Mycoplasma, Chlamydia, atypical Mycobacteria, Spirochetes, Actinobacillus, Bacillus anthracis, Listeria monocytogenes, Clostridium perfringens, Nucella spp. are susceptible to this product. Tetracycline hydrochloride acts better on gram-positive than gram-negative bacteria, but Enterococcus spp. and penicillin-resistant gonococci are resistant to it. Tetracycline hydrochloride has good antibacterial effect on gram-negative bacteria such as Vibrio, Brucella, Campylobacter, Yersinia, etc. It has no antibacterial activity against Pseudomonas aeruginosa.

Uses and functions of Tetracycline Hydrochloride.

Tetracycline hydrochloride is an antibiotic used for the treatment of non-bacterial infections such as chlamydial infections, rickettsial diseases, mycoplasma pneumonia, regression fever, etc. It is also used for the treatment of brucellosis, cholera, rabbit fever, rat-bite fever, anthrax, tetanus, bubonic plague, actinomycosis, gas gangrene, and respiratory, biliary, and urinary tract infections caused by sensitive bacteria, as well as soft-tissue skin infections.

Pharmacological Effect of Tetracycline Hydrochloride.

1. Tetracycline Hydrochloride is a broad-spectrum bacteriostatic agent with bactericidal effect at high concentration. It has certain antibacterial effect on Streptococcus pneumoniae, Streptococcus haemolyticus, Streptococcus pyogenes and some staphylococci, Bacillus pyogenes, Bacillus anthracis, Bacillus plague, Bacillus diphtheriae, Bacillus tetani, Brucella spp., Haemophilus influenzae, Campylobacter spp., and Vibrio cholerae, and it has inhibitory effect on Rickettsiae, Mycoplasma, Chlamydiae, Spirochaetes, and some protozoa.

Enterobacteriaceae such as Escherichia coli, Klebsiella spp, Salmonella spp, Shigella spp, etc. are mostly resistant to this product.

2, Tetracycline Hydrochloride is better than Gram-positive bacteria, but Enterococcus spp. are resistant to it. Others such as Actinobacillus spp., Bacillus anthracis, Listeria monocytogenes, Clostridium difficile, Nocardia spp. are also sensitive to this product.

Tetracycline Hydrochloride has some antibacterial activity against Neisseria gonorrhoeae and Neisseria meningitidis, but penicillin-resistant gonococci are also resistant to tetracycline. It has no antibacterial activity against Pseudomonas aeruginosa. For some anaerobic bacteria with some antibacterial effect, but far less than metronidazole, clindamycin and chloramphenicol, so the clinic is not selected.

Over the years, due to the wide application of tetracycline, the common clinical pathogens, including staphylococci and other gram-positive bacteria and enterobacteria and other gram-negative bacilli, tetracycline resistance phenomenon is serious, and there is a cross-resistance between similar species.

The mechanism of action of Tetracycline Hydrochloride is that the drug can specifically bind to the A position of the 30S subunit of the bacterial ribosome, preventing the linkage of aminoacyl-tRNA in this position, thus inhibiting the growth of peptide chain and affecting the synthesis of bacterial proteins.

Drug interactions of  Bulk Tetracycline Hydrochloridel Powder.

1、Tetracycline Hydrochloride can inhibit the activity of plasma plasminogen, so patients receiving anticoagulant therapy need to adjust the dose of anticoagulants.

2、Drugs containing metal ions such as calcium, magnesium, iron, etc., can form insoluble complexes with this product, so that the absorption of this product is reduced.

3、Combined with the general anaesthetic drug methoxyflurane, it can enhance its nephrotoxicity.

4, with strong diuretic drugs such as furosemide and other drugs can aggravate renal impairment.

5, with other hepatotoxic drugs (such as anti-tumour chemotherapy drugs) can aggravate liver damage.

6, lipid-lowering drugs Kaolai enamine or Kaolai Tipo can affect the absorption of this product, must be taken separately at intervals of several hours.

7, Tetracycline Hydrochloride can reduce the effect of contraceptive pills, increase the possibility of bleeding outside the period.

8, and acid-making drugs such as sodium bicarbonate when used together, due to the increase in pH value in the stomach, can make the absorption of this product to reduce the activity of the reduction, so should not be taken within 1-3 hours after taking this product to take acid-making drugs.