Apis and intermediates thereof Ceftiofur Sodium

CAS:104010-37-9

MF:C19H18N5NaO7S3

MW:547.55

EINECS:680-655-2

Specification: 99% min Ceftiofur Sodium Powder

Sample:Ceftiofur Sodium Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: Yellow Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Ceftiofur Sodium Powder Usage and Synthesis.

Ceftiofur has wide antibacterial spectrum and strong antibacterial activity, it has strong antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and some anaerobic bacteria, in which it is similar or weaker to Gram-positive bacteria compared with the first generation of cephalosporins, and it has strong antibacterial activity against Gram-negative bacteria such as Escherichia coli, Salmonella, Pasteurella, etc. It is suitable for the prevention and treatment of respiratory tract infections caused by various sensitive bacteria, especially for the early death of 1-day-old piglets.

It is suitable for respiratory and urinary tract infections caused by various sensitive bacteria, especially for the prevention and treatment of early death of chickens caused by E.coli, Salmonella, Pseudomonas aeruginosa, Staphylococcus, etc., E.coli yellow diarrhoea of 1-day-old piglets and wound infections caused by cutting umbilical cords, playing the ear trumpet, clipping teeth and tails, etc., as well as infectious pleuropneumonia in pigs and bronchopneumonia in cows caused by haemophilous Actinobacillus, which are not suitable for use in dairy cows and milking goats. It is generally not suitable for the treatment of mastitis in cows and dairy sheep.

The results of the bacteriostatic test of ceftiofur sodium on thousands of veterinary clinical isolates of pathogenic bacteria done by some researchers show that the drug is one of the strongest antibacterial activity of the drug, on Escherichia coli, multicidal and haemolytic Pasteurella, Salmonella typhi, Streptococcus spp. have a very strong antibacterial activity; Pseudomonas aeruginosa, Enterobacteriaceae spp. and anaerobic bacteria also have a very good effect.

It is mainly used for the treatment of respiratory diseases in horses, cattle, pigs (infectious pleuropneumonia), sheep, pets, and infectious diseases in 1-day-old broilers. This product has the characteristics of complete absorption by intramuscular injection and long elimination half-life.

Uses and functions of Ceftiofur Sodium.

Mainly used for livestock and poultry sensitive bacterial infections.

1、Infectious pleurisy, Actinobacillus actinomycetemcomitans, Pasteurella multocida, Streptococcus pyogenes, yellow and white diarrhoea in piglets, Salmonella, Haemophilus parahaemophilus, and atrophic rhinitis.

2, livestock prenatal and postpartum high fever, endometritis, mastitis, no milk less milk syndrome, hoof leaf inflammation, putrefactive hoof infection, cattle and sheep bacillus, transport fever, pneumonia, nasal atrophy, and so on.

Pharmacological Effect of Ceftiofur Sodium.

Broad-spectrum bactericidal action, effective against Gram-positive and Gram-negative strains. It is effective against Gram-positive, Gram-negative and lactamase-producing strains. Sensitive bacteria include Pasteurella, Actinobacillus, Salmonella, Streptococcus, Staphylococcus and so on.

The antimicrobial activity is stronger than ampicillin, and the activity against streptococci is also stronger than that of quinolone antimicrobials. Had isolated pathogenic bacteria from cattle respiratory disease material, after testing its M1C90 were: Pasteurella tolerans ≤ 0.06 (0.03~0.13), Pasteurella multocida ≤ 0.06 (0.03~0.25), Haemophilus lethargica (≤ 0.06 (0.03~0.13), which is highly sensitive. Bordetella bronchiseptica is resistant to this product.

The MIC90 against porcine pathogens were Actinobacillus pleuropneumoniae ≤0.03, Pasteurella multocida ≤0.03, Pasteurella multocida ≤0.03 and Salmonella cholera ≤01.0, Salmonella typhimurium 2.0 and Escherichia coli 1.0, respectively.

Poduction Method of Bulk Ceftiofur Sodium Powder.