Pharmaceutical raw materials Colistin Sulfate Powder

CAS:1264-72-8

MF:2(C52H98N16O13).5(H2SO4)

MW:2801.27

EINECS:215-034-3

Specification​: 99% min Colistin Sulfate Powder

Sample:Colistin Sulfate Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: white powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Colistin Sulfate Usage and Synthesis.

Mucorbicin Sulfate, also known as Mucorbicin Sulfate, Colistin, Polymyxin E, Anti Enemy, etc., white or almost white powder, odourless, bitter taste with moisture attraction, soluble in water, slightly soluble in methanol, ethanol, virtually insoluble in acetone, ether, etc., free base slightly soluble in water.

Stable in the range of PH3-7.5. Mucorbicin Sulfate is produced by Mucorbacterium polymorpha, which has strong antibacterial effect on Gram-negative bacteria, and is used for the treatment of intestinal diseases caused by Gram-negative bacteria, used as feed additives, and has obvious growth-promoting effect. It is used as feed additive and has obvious growth promoting effect. It is better to be used in combination with sulfadiazine.

Uses and functions of Colistin Sulfate.

Antibiotics, which is produced by the bacterium Viscum polymorpha, has a strong antibacterial effect against gram-negative bacteria and is used to treat intestinal diseases caused by gram-negative bacteria.

Mucorbicin sulphate is used, to penetrate cell membranes of bacteria and mannose for anticoagulation and antibiotic resistance studies in certain organisms, such as Bowman's. It has also been used to study hephrotoxicity in rat kidney, MIC values against Pseudomonas aeruginosa, time-kill kinetics, and post antibiotic effect (PAE).

It belongs to the antibiotic class of drugs and is used for the treatment of intestinal diseases caused by gram-negative bacilli, and has some growth-promoting effects.

Pharmacological activities of Colistin Sulfate.

The bactericidal activity of mucilage sulfate is mainly due to the structure of its molecular structure with three key active groups of fatty acids, positively charged amino acids and cyclic peptides. Lack or change of any one of these structures will greatly reduce its bactericidal activity.

Viscidin sulfate plays a bactericidal role, mainly positively charged free amino acids, can be combined with the negatively charged phosphate in the phospholipids in the plasma membrane of bacterial cells, so that the surface tension of the bacterial plasma membrane is lowered, and damage the integrity of the cell membrane, so that the permeability of the cell membrane is increased, so that the main components of the cell, especially purines, pyrimidines and so on, from the cell plasma flow, thus resulting in the growth of the bacteria is inhibited or causing bacterial Death.

Because the cell membrane of Gram-negative bacteria contains more phospholipids, while the cell membrane of Gram-positive bacteria contains very little phospholipids, so the antibacterial effect of Mucorbicin Sulfate is the strongest effect on Gram-negative bacteria.

In view of this, the antibacterial spectrum of mucin sulfate is also limited to gram-negative bacteria such as Escherichia coli, Salmonella, Pasteurella, Pseudomonas aeruginosa, Haemophilus and so on. Moreover, resistance of these bacteria to commonly used aminoglycosides, penicillins, cephalosporins, fluoroquinolones, etc. is quite common; moreover, many of them are multi-drug resistant.

Mucins sulfate, however, are not susceptible to resistance, and to date, no resistance has been found to be transmitted against the mucin sulfate resistance plasmid. Therefore, the spread of resistance to mucin sulfate is extremely slow, and the majority of Gram-negative bacteria are currently quite susceptible to mucin sulfate.

Specificities of  Bulk Colistin Sulfate Powder.

(1) Extremely strong against Gram-negative bacilli. Especially against Escherichia coli, Salmonella, Pseudomonas aeruginosa with specific development hindering effect.

(2) It has bactericidal effect. By hindering the selective permeability function of the cell membrane, so that the bacteria die

(3) Little or no drug resistance. No R-factor resistance has been detected.

(4) Acts synergistically with anti-Gram-positive bacterial drugs. Combined with zinc bacillus peptide, flavomycin, sulfonamides, semi-synthetic penicillin, gentamicin and so on, its effect is even better.

(5) No residue. When given orally, it is almost not absorbed by the intestines, but when injected intramuscularly, the blood receives and absorbs well, so there is no need to worry about the problem of residues in livestock products.

(6) Promote the growth of livestock and poultry, and prevent and control infectious enteritis of livestock and poultry.