Pharmaceutical intermediate Streptomycin Sulfate Powder

CAS:3810-74-0

MF:C21H41N7O16S

MW:679.65

EINECS:223-286-0

Specification: 99% min Streptomycin Sulfate Powder

Sample:Streptomycin Sulfate Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Streptomycin Sulfate Powder Usage and Synthesis.

Streptomycin sulphate has strong antibacterial effect on Mycobacterium tuberculosis, not strong on most gram-positive cocci (e.g. various streptococci) and bacilli (e.g. Pseudomonas aeruginosa, anaerobic bacilli), and strong antibacterial effect on many gram-negative bacilli, it is effective for all kinds of cutaneous tuberculosis, and it has the effect of inhibiting the reproduction of Mycobacterium tuberculosis and the production of toxin, and it has a High concentration (>0.4μg/mL) has bactericidal effect.

Mycobacterium tuberculosis resistance to streptomycin occurs rapidly, it is advisable to combine with other anti-tuberculosis drugs.

Streptomycin sulfate and another has been approved for extra-gastrointestinal application of high-efficiency bactericides isoniazid, can be susceptible to bacteria immediately produce significant therapeutic effect, in critical cases, often can receive the effect of the resurrection of the dead. Streptomycin sulphate is most effective in the first weeks or months of treatment.

Perhaps because the product is applied parenterally from the gastrointestinal tract, the serum concentration increases rapidly, so it seems to enhance the effectiveness of oral medication, and even highly effective drugs such as ethambutol and isoniazid can benefit from the combination of this product.

Uses and functions of Streptomycin Sulfate.

Streptomycin sulfate is effective against Gram-positive and Gram-negative bacteria, but less effective than penicillin G against Gram-positive bacteria such as streptococci and pneumococci, and is ineffective against rickettsiae, protozoa, viruses, and fungi; it is effective against Mycobacterium tuberculosis and a variety of Gram-negative bacteria such as Escherichia coli, Borrelia burgdorferi, Mycobacterium aerogenes, Mycobacterium influenzae, Mycobacterium dysenteriae, Mycobacterium bovis, and so on.

It is mainly used for the treatment of tuberculosis, bone tuberculosis, lymphatic tuberculosis, intestinal tuberculosis, tuberculous meningitis and meningitis caused by sensitive strains of Mycobacterium tuberculosis, pneumonia, septicaemia, pyothorax, pleurisy, peritonitis, etc., and it can be used for urinary and respiratory infections caused by sensitive strains of Mycobacterium tuberculosis.

Pharmacological Effect of Streptomycin Sulfate.

Streptomycin Sulfate has antibacterial effect on most Gram-positive and negative bacteria, especially on many Gram-negative bacilli such as Escherichia coli, Salmonella, Bartonella, Borrelia burgdorferi, Pneumococcus, Dysentery bacilli, Aerobacter aerogenes, and Bacillus nosocomialis.

This product is the first choice of anti-tuberculosis mycobacteria, strong effect on tuberculosis mycobacteria, in low concentration has a strong bacteriostatic effect, high concentration has a bactericidal effect. Because only 10% can penetrate into the body cells, so it is ineffective against intracellular tuberculosis bacteria, and can only kill extracellular tuberculosis bacteria.

It has a stronger bactericidal effect on bacteria in the reproductive phase than on bacteria in the resting phase.

Unlike penicillin, its bactericidal rate is proportional to the concentration of the drug, and its antimicrobial effect is strongest at pH 7.8, and the effect is greatly weakened when the pH is reduced to below 6. Agricultural Streptomycin Sulfate is an antibiotic fungicide, which can prevent and control many kinds of bacterial diseases of crops, and also have some preventive effect on some fungal diseases.

According to China's pesticide toxicity classification standards, streptomycin is a low-toxicity fungicide. The acute oral LD50 of the original drug in rats is >9000mg/kg body weight. It can cause skin allergic reaction.

Drug interactions of  Bulk Streptomycin Sulfate Powder.

1, Streptomycin has a synergistic effect with penicillins or cephalosporins.

2, Antibacterial effect is enhanced in alkaline environment, combined with alkaline drugs (such as sodium bicarbonate) can enhance antibacterial efficacy.

3, Ca2+, Mg2+, Na+, NH+4, K+ and other cations can inhibit the antimicrobial activity of this product.4, Streptomycin sulphate in combination with cephalosporins and erythromycin enhances the ototoxicity of this class of drugs.