Buy Drospirenone API powder C24H30O3 supplier

CAS: 67392-87-4

MF: C24H30O3

MW: 366.5

EINECS: 266-679-2

Specification​: 99% min Drospirenone Powder

Sample: Drospirenone Powder Avaliable

Packaging: 1kg/bag, 25kg/drum

Brand: Ausreson

MOQ: 1 kg

Appearance:  White to Off-White powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Last updated: March 2026

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Drospirenone Powder Usage and Synthesis.

Drospirenone, a new synthetic progestin designed to mimic the effects of progesterone, is the progestin with pharmacological properties closest to those of natural progesterone, combining the unique advantages of anti-salt corticosteroid and anti-androgenic activity.

It appears as a form of fertility control hormone. By mimicking progesterone, it increases hormone levels and reduces the risk of pregnancy. It was therefore marketed as an effective contraceptive.

Unfortunately, since its introduction to the market, Drospirenone has shown negative effects on female estrogen. The mixing of these two hormones can adversely affect the health of some people.

How Drospirenone Sculptures the Internal Environment

• Anti-Mineralocorticoid Activity: Drospirenone antagonizes the Renin-Angiotensin-Aldosterone System (RAAS). In 2026, this is the #1 reason for its use in preventing estrogen-induced water retention, sodium storage, and breast tenderness.

• Anti-Androgenic Shield: By blocking androgen receptors, it reduces sebum production and prevents the hirsutism (excess hair growth) and Acne often triggered by other synthetic progestins.

• Stable Blood Pressure Support: Due to its mild diuretic effect, 2026 clinical data highlights its role in maintaining stable blood pressure levels in women transitioning through perimenopause.

• Minimal Impact on Glucose Metabolism: Unlike older progestins, Drospirenone has shown a neutral effect on insulin sensitivity in 2026 studies, making it a safer option for women with metabolic concerns.

Uses of Drospirenone.

Drospirenone, also known as dihydrospirenone, chemically known as 6β,7β,15β,16β-di-methylene-3-oxo-17α-pregn-4-ene-17,21-carboxylic lactone, is a natural progesterone activity of lactone progestins developed by the German company Schering (ScheringAG).

Clinically, it is usually combined with ethinylestradiol to form a combination estrogen-progestogen preparation as a commonly used oral contraceptive for women, also known by the trade name Yasmin.

In addition to being a highly effective contraceptive, Yasmin also has clinical applications such as anti-salt corticosteroid activity, prevention of weight gain caused by fluid retention, and improvement of skin and hair.

Why "99.5% Micronized Pharma-Grade" is the 2026 Standard

1. Low Dose, High Precision: Drospirenone is effective at very low concentrations (typically 2mg - 4mg). In 2026, Micronized Drospirenone Powder is essential for ensuring uniform distribution in the final tablet or gel, preventing "hot spots" of active ingredient.

2. Ultra-High Purity ($\geq$ 99.5%): For chronic, long-term use in HRT, 2026 standards demand a near-perfect purity profile (HPLC) to eliminate impurities like spironolactone analogs that could interfere with targeted receptor binding.

3. Stability in Complex Matrices: Premium 2026 powders are engineered to be stable when combined with various estrogens (like Estradiol Enanthate or Valerate), ensuring a consistent shelf life of 36+ months.

Side Effects of Drospirenone.

When drospirenone reacts with estrogen, it can cause the blood in the body to thicken. It may seem like a minor problem, but blood clotting can lead to the formation of blood clots.

These clots that form in the blood vessels can impede the flow of blood and even block the heart, brain, lungs and other vital organs directly with the flow of blood.

Clots interfere with the heart receiving blood and can cause a heart attack. If it interferes with blood flow to the brain, it causes a stroke.

The possibility of side effects exists for any woman taking drospirenone, but people who are obese, diabetic, smokers, depressed, or have high blood pressure are more likely to develop blood clots from taking drospirenone-containing birth control pills.

FAQ.

In 2026, we clarify: Levonorgestrel (2nd Gen) is often associated with bloating and androgenic side effects. Drospirenone (4th Gen) is designed to counteract these issues, making it the "Premium Choice" for women sensitive to weight gain or skin changes.

Absolutely. In 2026, Drospirenone powder is a key ingredient in Combined MHT, where it protects the uterine lining while simultaneously managing the bloating and mood disturbances common in menopause.

Because Drospirenone has potassium-sparing properties, 2026 protocols recommend that patients with kidney issues or those taking ACE inhibitors monitor their potassium levels, though this is rarely an issue for healthy individuals at standard doses.

The most common daily dose in oral formulations is 3mg to 4mg, often paired with $0.02mg$ or $0.03mg$ of Ethinyl Estradiol or $1mg$ of Estradiol.

User comment.

“As a patient with polycystic ovary syndrome, YAZ not only provided reliable birth control, but also made my skin fairer than ever before.” - 26-year-old designer

“After experiencing edema on two traditional birth control pills, switching to drospirenone eventually eliminated the 'bloated feeling'.” - 31-year-old fitness instructor

Our Strengths

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