Feed Additive Erythromycin base Powder

CAS:114-07-8

MF:C37H67NO13

MW: 733.93

EINECS:204-040-1

Specification​: 99% min Erythromycin base Powder

Sample:Erythromycin base Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Erythromycin base Powder Usage and Synthesis.

Erythromycin is a gastric actin receptor agonist. The dimethylamine group and the 14-membered lactone ring on the glycosidic chain of the erythromycin molecule have a similar spatial structure to that of gastric actin, which can act as a gastric actin receptor agonist and produce a mimetic gastric actin effect, inducing early onset of MMC phase III contractions in the fasting state and causing contractions of the gastric and duodenal smooth muscles.

The pro-gastric dynamic effect of erythromycin is dose-dependent. Low doses of erythromycin induce gastric contractions similar to those of spontaneous MMC, whereas high doses of erythromycin cause strong irregular gastro-duodenal contractions inducing vomiting, which is the reason why erythromycin induces gastro-intestinal reactions .

Therefore, erythromycin should not be used in excessive doses for gastric motility.

Clinically used in penicillin-resistant Gram bacterial infections and penicillin allergic patients, Legionella pneumonia, Mycoplasma pneumonia, Chlamydia trachomatis caused by infantile pneumonia and colitis, skin and soft tissue infections can be used as a drug of choice, and can be used for haemolytic streptococcus and pneumococcus caused by respiratory infections, diphtheria carriers, the efficacy of the product and diphtheria antitoxin combined with the enhancement of the efficacy of the drug.

Uses and functions of Erythromycin base.

Erythromycin can be used to treat digestive system diseases, EM has different degrees of prokinetic effect on the whole gastrointestinal tract.

It mainly has the following effects: promoting oesophageal contraction and increasing the lower oesophageal sphincter pressure (LESP); promoting gastric sinus contraction, improving the coordination of gastric sinus and duodenal function; inducing gastrointestinal migratory complex movement; promoting colonic movement and gallbladder contraction, and so on.

Therefore, it can effectively treat gastrointestinal diseases.

Erythromycin is a commonly used macrolide antibiotic with similar antibacterial spectrum as penicillin, mainly used for penicillin allergic patients, or penicillin-resistant Aureobasidium infections, also used for streptococcus, pneumococcus infections and diphtheria carriers.

Inhibits the extended phase at the transpeptide step, inhibits bacterial protein synthesis by binding to the ribosome, and induces erythromycin resistance in bacteria. Antimicrobial spectrum: Gram-negative and positive bacteria. A macrolide antibiotic.

Pharmacological Effect of Erythromycin base.

1, Erythromycin is a macrolide antibiotic. It has antibacterial activity against staphylococci (except methicillin-resistant strains), streptococci and gram-positive bacilli.

Neisseria, Haemophilus influenzae, Bordetella pertussis are also sensitive to this product.

Erythromycin also has antibacterial effect on various anaerobes except Clostridium perfringens and Clostridium difficile.

It can also inhibit Legionella, Campylobacter fetus, some spirochetes, Mycoplasma pneumoniae, Rickettsia and Chlamydia.

2, Erythromycin can be through the bacterial cell membrane, in close proximity to the donor site ("P" site) and the 50S subunit of the bacterial ribosome into a reversible binding, blocking the transfer of ribonucleic acid (t-RNA) binding to the "P" site, but also block the polypeptide chain from the acceptor ("A" site), the polypeptide chain from the acceptor ("A" site), the polypeptide chain from the "A" site. It also blocks the displacement of polypeptide chains from the acceptor site ("A" site) to the "P" site, thus inhibiting bacterial protein synthesis.

Production method of Bulk Erythromycin base Powder.

This product is an alkaline antibiotic extracted from the culture fluid of Streptomyceserythreus. For purification, using its property of dissolving in different solvents at different acidity and alkalinity, it is repeatedly extracted with butyl acetate and aqueous solution to achieve the purpose of concentration and purification, and finally cryocrystallised in butyl acetate solution to obtain erythromycin base.