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Fluoxetine Hydrochloride Powder 56296-78-7
Product Overview:
Fluoxetine hydrochloride is the first selective 5-hydroxytryptamine reuptake inhibitors (SSRIs) antidepressant on the market in the world, with the trade name of "Prozac", which was firstly developed by Eli Lilly and Company in the United States. Fourteen years after the discovery of fluoxetine, it was firstly approved to be used for the treatment of depression in Belgium in 1986, and was approved by FDA to enter the US market at the end of 1987, under the trade name of Prozac, which became the best-selling antidepressant in the United States, and ushered in a new era of effective treatment of depression with good safety.
Fluoxetine Hydrochloride Powder 56296-78-7 Attributes
CAS:56296-78-7
MF:C17H19ClF3NO
MW:345.79
EINECS:260-101-2
Specification: 99% min Fluoxetine Hydrochloride Powder
Sample: Fluoxetine Hydrochloride Powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance: White powder
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Fluoxetine Hydrochloride Powder 56296-78-7 Details
Fluoxetine Hydrochloride Powder Usage and Synthesis.
As fluoxetine is the first 5-HT reuptake inhibitor antidepressant on the market, it has a different structure and pharmacological mechanism from previous TCAs antidepressants.
With its precise efficacy and mild side effects, it has been favoured since its introduction to the market, and its sales have increased significantly year after year.
Since the 1970s, when Eli Lilly and Company developed fluoxetine, it has created a number of brilliant, a generation of legend, opening up a new chapter in the treatment of depression medication.
Although the market declined after 2001, but is still one of the commonly used drugs for antidepressant treatment.
Fluoxetine hydrochloride can be used for all types of depression, especially for depressive symptoms associated with organic disease and depression in old age. It is also used to treat post-schizophrenic depression.
It is also used for obsessive-compulsive disorder, phobias, anxiety symptoms of depression, bulimia nervosa, weight loss and as an adjunctive treatment for smoking cessation.
Uses of Fluoxetine Hydrochloride.
Fluoxetine hydrochloride can be used for all types of depression, especially for depressive symptoms associated with organic disease and depression in old age. It is also used to treat post-schizophrenic depression.
It is also used for obsessive-compulsive disorder, phobias, anxiety symptoms of depression, bulimia nervosa, weight loss and as an adjunctive treatment for smoking cessation.
Pharmacological Effect of Fluoxetine Hydrochloride.
Fluoxetine blocks 5-HT2A receptors and restores DA and NE levels through inhibition of 5-HT2A receptors. At the same time, fluoxetine also relieves the inhibitory effect of gamma-aminobutyric acid (GABA) neurons on NE and DA release via 5-HT2C receptors.
In addition to its ability to increase the 5-HT concentration in the synaptic gap, it is based on fluoxetine's action on 5-HT2A and 5-HT2C that directly and indirectly restores the levels of DA and NE, with NE and DA derepression properties (NDDI).
Adverse Reaction of Bulk Fluoxetine Hydrochloride Powder.
The main adverse effects of fluoxetine hydrochloride are nausea, nervousness and insomnia, which disappear on their own after stopping the drug. Other side effects are headache, anxiety, excessive sweating, diarrhoea, blurred vision, dry mouth and sexual dysfunction.
