Natural Sanchi Extract Powder

CAS:80418-29-7

MF:H6NO4SZn+

MW:181.49

EINECS:/

Specification​: 99% min Sanchi Extract Powder

Sample:Sanchi Extract Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:Brown

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Sanchi Extract Powder Usage and Synthesis.

Panax ginseng extract is an active substance extracted from Panax ginseng plant, which has various effects. 

In recent years, it has been found that the active substances such as saponins and polysaccharides in Panax ginseng extract have better whitening, anti-aging and anti-inflammatory effects on beauty and skin care, and are therefore widely used in the cosmetic market. In addition, Panax ginseng extract has the effects of activating blood circulation and removing blood stasis, reducing swelling and analgesia, etc. 

It is used in the production of medicines and health food, such as high-activity injections, high-purity oral dosage, and high-security soft gelatin capsules, which are widely used in the prevention of cardiovascular and cerebral vascular diseases and related health care.

Uses of Sanchi Extract.

Dispersing blood stasis and stopping bleeding, subduing swelling and relieving pain. Used for haemoptysis, vomiting blood, epistaxis, haematochezia, leakage, bleeding from trauma, stabbing pain in the chest and abdomen, bruises and injuries.

Pharmacological Effect of Sanchi Extract.

Effects on blood and haematopoietic system: Panax ginseng has strong haemostatic effect, anti-platelet aggregation and thrombolytic effect, haemolytic effect, haematopoietic effect.

Anti-inflammatory effects: The aqueous extract of Panax ginseng root, 50~200mg/kg subcutaneously, can inhibit the increase of skin vascular permeability caused by hyaluronidase, chondroitinase ABC, α-chymotrypsin and histamine by 11%~36%.

Total saponin of Panax ginseng root, on the keratine gum, kaolin, 5-hydroxytryptamine, egg white, hyaluronidase-induced small mouse or rat ankle joint swelling, foot swelling and so on have inhibitory effect. In addition, the total saponin of Panax ginseng has obvious inhibitory effect on the swelling of mouse auricle caused by xylene and croton oil.

Effects on immune function: Panax ginseng total saponin 160mg/kg can increase the number of haemolytic vacuoles in mice by 92%, and also increase the phagocytosis rate and phagocytosis index of abdominal macrophages in mice.

It can significantly increase the phagocytosis rate of rat alveolar macrophages, increase the total number of leukocytes and the percentage of lymphocytes in blood, and reduce the leukocyte migration index.

Anti-tumour effect: Panax ginseng saponin Rb1120μg/ml can inhibit 92% of cultured tumour cells, while only 29% of cultured normal cells were inhibited, and Rd also had a significant inhibitory effect on cultured tumour cells.

Saponin RChemicalbookh1, also inhibited isolated hepatocellular carcinoma cells, which acted directly on the cell membrane. Saponin Rh2 inhibited the growth of mouse melanoma (B16) in a concentration-dependent relationship, and induced the reversal of cancer cell redifferentiation into non-cancer cells.

Extraction Processes of Bulk Sanchi Extract Powder.

Total saponins of Panax ginseng are soluble in water and ethanol, but considering that Panax ginseng contains a large amount of starch, it is not suitable to use water or low concentration of ethanol to avoid pasteurisation; for this reason, 75% ethanol was chosen as the extraction solvent.

Percolation method: Panax pseudoginseng was crushed into coarse powder (20-40 mesh), soaked in 75% ethanol for 12h, then slowly percolated at a degree of about 2mL/kg-min-1, and the percolating solution equivalent to the selected amount of Panax pseudoginseng was collected, which was obtained by decompression, concentration and vacuum drying.

Hot immersion method: Panax pseudoginseng was crushed into coarse powder (20-40 mesh), soaked in 75% ethanol for 12h, and then extracted by hot immersion at 60°C for 3 times, each time the extraction time was about lh, the filtrate was collected and combined, and then concentrated under reduced pressure and dried in vacuum.

Thermal reflux method: Panax pseudoginseng was crushed into coarse powder (20-40 mesh), added with 75% ethanol, soaked for about 12h, ultrasonication for 30min for 3 times, filtered, collected and combined filtrate, concentrated under reduced pressure and vacuum dried.

Ultrasonic extraction method: Panax pseudoginseng was crushed into coarse powder (20-40 mesh), added 75% ethanol, soaked for about 12h, ultrasonic 30min, a total of 3 times, filtration, collection of the combined filtrate, concentration under reduced pressure, vacuum drying. The extraction effect of reflux method and percolation method was almost the same, and both processes were feasible.

However, due to the possibility of destruction of Panax notoginseng saponins by heat, and the easier operation of percolation method in the production practice, the extraction process of Panax notoginseng was better than percolation method.