Raw Materials Diammonium Glycyrrhizinate Powder

CAS:79165-06-3

MF:C42H65NO16

MW:839.97

EINECS:1308068-626-2

Specification: 99% min Diammonium Glycyrrhizinate Powder

Sample:Diammonium Glycyrrhizinate powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:White

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Diammonium Glycyrrhizinate Powder Usage and Synthesis.

Diammonium glycyrrhizinate is an active ingredient extracted from the traditional Chinese medicine liquorice, which has strong anti-inflammatory, hepatocyte membrane protection and liver function improvement effects, and has a preventive and curative effect on liver injury caused by a variety of hepatotoxic agents in a dose-dependent manner.

Experiments have proved that diammonium glycyrrhizinate can significantly prevent the increase of serum alanine aminotransferase (ALT) induced by galactosamine, carbon tetrachloride and thioacetamide, and improve the damaged tissues of the liver.

The indication of Diammonium Glycyrrhizinate Injection is for the treatment of chronic hepatitis, and the dosage should follow the doctor's instruction.

It should be noted that the instruction manual of Diammonium Glycyrrhizinate Injection is the suggested reference draft after the specification revision, and the enterprise can propose the modification if there is any doubt.

Uses and functions of Diammonium Glycyrrhizinate.

Diammonium glycyrrhizinate is suitable for the treatment of acute and chronic viral hepatitis, especially for chronic active hepatitis B and chronic active hepatitis C. It can significantly improve clinical symptoms and liver function, and its efficacy is better than that of monoammonium glycyrrhizinate and adrenocorticotropic hormone.

Pharmacological Effect of Diammonium Glycyrrhizinate.

Diammonium glycyrrhizinate is a diammonium salt of α-glycyrrhizinate isolated and screened out from liquorice, which is a replacement product of potentin (monoammonium salt of β-glycyrrhizinate).

Diammonium glycyrrhizinate and monoammonium glycyrrhizinate have similar pharmacological effects, hormone-like effects and immunomodulatory effects, with strong anti-inflammatory, hepatocyte membrane protection, immunomodulation and improvement of liver function.

Pharmacological experiments have proved that: oral administration of this product in mice can reduce the elevation of serum ghrelin and ghrelin induced by carbon tetrachloride, thioacetammonium and D-amino-galactose, and it can also significantly reduce the morphological damage of D-amino-galactose to the liver and improve the chronic damage of immune factors to the morphology of the liver.

Diammonium glycyrrhizinate injection has the effects of anti-inflammation, anti-allergy, protecting the structure of hepatocyte membrane and lysosomal membrane, regulating immunity and inducing interferon, etc. It is clinically used for chronic prolonged hepatitis and chronic active hepatitis accompanied by the elevation of glutamate aminotransferase.

Caveat of Bulk Diammonium Glycyrrhizinate Powder.

1. It is forbidden to use in patients with severe hypokalemia, hypernatremia, cardiac failure, renal failure, pregnant women should not use it, and newborns, infants and young children should not use it for the time being.

2. This product cannot be injected without dilution.

3. Blood pressure and serum potassium and sodium concentration should be measured regularly during the course of administration. If hypertension, sodium retention or hypokalemia occurs, the drug should be suspended or the dosage should be reduced appropriately.

4. This product can be used orally and by injection. It can be given intravenously when aminotransferase is elevated, and can be maintained orally when aminotransferase tends to be normalised or during the recovery period.

5. Diammonium glycyrrhizinate injection is a new product in China, the application cases are not much, the clinical efficacy and adverse reactions have to be further verified by clinicians.