Celastrol Raw Materials Celastrol powder

CAS:34157-83-0

MF:C29H38O4

MW:450.61

EINECS:636-472-5

Specification: 99% min Celastrol powder

Sample:Celastrol powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: Red

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Celastrol powder Usage and Synthesis.

In modern medicine, one of the most important active components of tretinoin, tretinoin erythropoietin, has been found to be used in the treatment of obesity, chronic inflammation and immune disorders.

In 2007, tretinoin, artemisinin, tretinoin, capsaicin and curcumin were listed in the journal Cell as the five natural compounds most likely and most deserving of development as modern medicines.

Although high doses of tretinoin have some cardiotoxicity, low doses of tretinoin have been found to be cardiovascular protective, and its exact efficacy, intrinsic mechanism and unknown targets have attracted the attention of many scientists.

Uses of Celastrol powder.

Leigongdengrongxin is a natural product with a variety of biological activities, and its source of extraction is the whole plant or peeled woody part of Leigongdeng, a plant of the family Wistariaceae.

Modern studies have shown that tretinoin has a strong antioxidant effect, can resist cancer neoangiogenesis, anti-rheumatoid effect and so on.

In addition, tretinoin has been found to have weight loss, antidiabetic, and fatty liver reduction effects, and its mechanism of action is mediated through interleukin 1 receptor 1 (IL1R1).

The treatment of ulcerative colitis with tretinoin is realised by modulating immunity through the gut flora; therefore, other diseases associated with long-term chronic inflammation, such as rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis and allergies, cancer and neurodegenerative diseases may also be associated with the gut flora.

In conclusion, tretinoin is a natural active product of interest with a wide range of biological activities and therapeutic potential.

Pharmacological Effect of Celastrol powder.

1, Cytotoxic activity. Strong non-specific cytotoxic activity against P388 and a group of human cancer cell lines in vitro.2, Immunomodulatory effect. Significantly inhibited the formation of haemolytic vacuole cells in mouse splenocytes. Significantly inhibited the delayed hypersensitivity reaction in mice.

3, Anti-inflammatory effect: At 0.5mg/kg, it significantly inhibited the formation of cotton ball granuloma in rats; at 0.1-1.0μg/mL, it inhibited the production of PGE2 induced by yeast sugar; at 1.0μg/mL, it inhibited phagocytosis of macrophages.

4, The anti-peroxidation effect of tretinoin is 15 times that of tocopherol, with an IC50 of 7 μM. It inhibits peroxidation inside and outside the mitochondrial membrane and scavenges free radicals directly.

5，Reglanin can prolong the sleep time of mice caused by sodium pentobarbital.

6, Immunosuppressive effect: inhibit the proliferation of splenocytes induced by PHA, ConA, LPS, etc. in mice, inhibit the proliferation of lymphocytes.

7, Inhibit the fertilisation ability of guinea pig spermatozoa in vitro, the activity is significantly stronger than that of cotton wool acetate.

8, Anti-arthritic effect. Inhibit the activity of interleukin-1 inside and outside mouse peritoneal macrophages, inhibit the production of interleukin-2 by mouse splenocytes, and reduce the release of PGE2 by rabbit synovial cells.

Preparation method of Bulk Celastrol powder.