Raw Materials Chrysophanic acid Powder

CAS:481-74-3

MF:C15H10O4

MW:254.24

EINECS:207-572-2

Specification: 99% min Chrysophanic acid Powder

Sample:Chrysophanic acid powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:Orange Yellow

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Chrysophanic acid Powder Usage and Synthesis.

It is mainly derived from the roots and rhizomes of Rhubarbum palmatum, family Polygonaceae. Rheumol has antibacterial effects on a variety of bacteria, such as Streptococcus A, Pneumococcus, Influenza bacillus and Cattleya. In addition, it can relieve cough, promote intestinal motility, induce nerve excitation and muscle paralysis, and also has a significant inhibitory effect on melanoma in mice.

Uses and functions of Chrysophanic acid.

Rhubarbol is an active ingredient present in herbs such as aloe vera and sea cucumber, which has a variety of efficacies and effects.

According to Chinese medicine, rhubarb phenol has the effects of laxative, clearing the liver and eyesight, and killing insects, etc. Modern medicine also often uses it for anti-inflammatory, antiseptic, and promoting wound healing.

Rhubarb phenol can also enhance immune function, anti-tumour, detoxification and laxative, antibacterial, anti-gastric injury and hepatoprotective as well as skin protection effects.

In addition, rhubarb phenol and other active ingredients rich in Duduwangfu sea cucumber can nourish the kidney yang and enhance male sexual function and fertility.

In conclusion, rhubarb phenol is an active ingredient with various effects and functions, which has a positive impact on human health.

Pharmacological Effect of Chrysophanic acid.

It is used in treating pain in the chest and ribs, rheumatism and paralysis, obstruction in the abdomen, sores, swelling and pain, bruises and injuries, menstrual disorders, menstrual amenorrhoea, post-partum stasis and pain. It is effective in treating pain in the chest and ribs, masses in the abdomen and abdomen, as well as irregular menstruation and menstrual pain, often used in combination with Rhizoma Ligustici Chuanxiong. In the treatment of chest and abdominal pain which is caused by stagnation of qi and blood stasis, it is often used together with sandalwood and sandalwood.

In vitro studies of Bulk Chrysophanic acid Powder.

Chrysophanic acid is an EGFR/mTOR pathway inhibitor.Chrysophanicacid is a naturally occurring anthraquinone compound with anticancer activity in EGFR overexpressing SNU-C5 human colon cancer cells.

Chrysophanic acid preferentially blocks the proliferation of SNU-C5 cells, but not other cell lines (HT7, HT29, KM12C, SW480, HCT116 and SNU-C4) with lower levels of EGFR expression.

Chrysophanic acid treatment of SNU-C5 cells inhibited EGF-induced phosphorylation in EGFR and suppressed the activation of downstream signalling molecules such as AKT, extracellular signal-regulated kinase (ERK), and mammalian target of rapamycin-like protein (mTOR)/ribosomal protein S6 kinase (p70S6K).

In BGM (Buffalogreenmonkey) kidney cells, Chrysophanicacid was also able to inhibit poliovirus types II and III (small RNA virus family) and poliovirus-induced cytopathic effects.