Rhein Raw Materials Rhein powder

CAS:478-43-3

MF:C15H8O6

MW:284.22

EINECS:207-521-4

Specification: 99% min Rhein Powder

Sample:Rhein Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: Yellow

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Rhein Powder Usage and Synthesis.

Rhubarb acid has anti-tumour activity, antibacterial activity, immunosuppressive effect, diuretic effect, laxative effect, anti-inflammatory effect, treatment of diabetes, kidney disease. Health care products are mainly used for lipid-lowering and weight loss, laxative and detoxification, cleansing the internal environment, preventing gastric cancer, and delaying aging.

Uses of Rhein.

Rhubarbic acid is a naturally occurring anthraquinone compound found in herbs such as rhubarb, aloe vera and senna. Studies have shown that rhubarb acid has a variety of pharmacological effects.

Firstly, rhubarb acid has the unique efficacy and new pharmacological characteristics of improving abnormal glucose metabolism, reversing insulin resistance and effectively preventing diabetic nephropathy.

Researchers found that rhubarb acid can play its role in the treatment of diabetic nephropathy by inhibiting the function of cellular glucose transporter protein 1, inhibiting the activity of cellular glucose metabolism hexosamine pathway loaded, inhibiting the expression of endothelial cell Rating B Yunmujiang Tablet Bixi Sin Si PAI-1, protecting the function of endothelial cells, and reversing the resistance of pancreatic islet face social laminin and other mechanisms.

Secondly, rhubarbic acid also has good ACE2 inhibitory effect, which may be the main active ingredient of Lianhua Qingdian exerting ACE2 inhibitory effect.

In addition, rhubarbic acid shows therapeutic effects in several inflammatory conditions, such as chronic glomerulonephritis, arthritis and acute enteritis.

Rhubarbic acid has also been shown to modulate the intestinal microbiota and purine metabolism in the gut to alleviate chronic colitis, as well as to protect the epithelial barrier in cytokine-stimulated intestinal epithelial cells.

Immunomodulatory effects on NLRP3 inflammasome activation in macrophages in vitro and in vivo have also been demonstrated in studies.

In conclusion, rhubarbic acid has a variety of pharmacological effects, including the treatment of diabetic nephropathy, inhibition of ACE2 activity, and the treatment of inflammatory diseases.

Pharmacological Effect of Rhein.

Both rhubarbic acid and rhodopsin have anti-tumour effects, especially strong inhibition of melanoma, and some inhibition of breast cancer and Ehrlich ascites carcinoma.

Intratumoural administration of rhubarb to mice with breast cancer showed significant destruction of cancerous tissues.

The inhibition rate of 5mg/kg of rhubarbic acid and rhubarbine on mouse melanoma was 76% and 73%, respectively. There was a significant competitive inhibition of tyrosinase by rhubarb, and this inhibition may be one of the mechanisms of rhubarb's antimelanoma action. The concentration of rhubarb at 10 μg/ml had an inhibitory effect on the division of human lung cancer A-549 cells, and had a significant inhibitory effect on the DNA biosynthesis of lung cancer A-549 cells.

The subcutaneous injection of the crude extract of rhubarb into k inhibited the sarcoma S37 in mice.

Rhubarb acid inhibited Ehrlich ascites carcinoma by 15% and mouse sarcoma S180 by 21%. Hot water extract of rhubarb inhibited mouse sarcoma S180 by 48.8%.

Rhubarb acid inhibited mouse leukaemia P388. Rhubarb acid, rhubarbol and aloe rhubarbol were extracted from rhubarb. All three anthraquinone derivatives reduced the amount of ascites and the number of cancer cells in tumour-bearing mice to varying degrees, with rhubarbic acid having a more pronounced effect and aloe rhubarbin a lesser effect, essentially paralleling prolonged survival.

The inhibitory effects on DNA, RNA and protein biosynthesis were stronger for rhubarbic acid and rhodopsin, and weaker for aloe rhodopsin.

Preparation method of Bulk Rhein Powder.