Prostaglandin E1 Raw Material Powder

CAS: 745-65-3

MF: C20H34O5

Specification​: 99% min Prostaglandin E1 Powder

Sample:  Prostaglandin E1 Powder

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Prostaglandin E1 Powder Usage and Synthesis:

Prostaglandin E1 (PGE1) is a naturally occurring hormone-like substance that is produced in the body. It is a member of the prostaglandin family of lipid compounds that are involved in a variety of physiological processes, including inflammation, pain, and blood clotting.

PGE1 has several therapeutic applications, including the treatment of erectile dysfunction, peripheral vascular disease, and Raynaud's disease. It is also used in the treatment of certain types of cancer, such as bladder cancer and pancreatic cancer.

PGE1 works by relaxing the smooth muscles in the blood vessels, which increases blood flow to the affected area. This can help to improve symptoms such as erectile dysfunction and peripheral vascular disease.

PGE1 can be administered in a variety of ways, including injection, topical Application, and oral ingestion. It is important to follow the instructions of a healthcare professional when using PGE1, as it can have side effects and interactions with other medications.

Pharmacokinetics of Prostaglandin E1 Powder:

ProstaglandinE1 (ProstaglandinE1) is also known as Alprostadil, Prodaxin, Kais and Capgemini. As a member of the prostaglandin family, prostaglandin E1 is a widely existing bioactive substance in the body and a recognized endogenous physiological active substance.

Prostaglandin E1 directly acts on vascular smooth muscle, dilates blood vessels, improves blood flow, and improves microcirculation perfusion. And inhibit platelet aggregation and thrombin A2 production, inhibit atherosclerosis, lipid plaques and immune complex formation; 

Dilate peripheral small vessels and coronary arteries, reduce peripheral vascular resistance and blood pressure, protect platelet cell membrane, prevent thrombosis;

Protect ischemic myocardium, reduce myocardial infarction area; Anti-heart failure; Dilate renal vessels, increase renal blood flow, remove non-protein nitrogen, regulate water and sodium balance, with diuretic and protect renal function.

Clinical Application of Prostaglandin E1 Powder:

Prostaglandin E1 Powder Clinical applications for complications of diabetes, coronary heart disease, refractory heart failure, congenital heart disease with pulmonary hypertension, hypertension, cerebral infarction, chronic arterial occlusion, sudden deafness, retinal vein occlusion, viral hepatitis, chronic gastritis, duodenal ulcer, chronic renal insufficiency, pancreatitis, organ transplantation, erectile dysfunction, labor induction and postpartum delivery Blood, femoral head necrosis, lumbar disc herniation, postherpetic neuralgia, bronchial asthma.

Treatment of hepatitis cirrhosis, cerebral infarction, diabetes, impotence, respiratory diseases. The liver function damage is not serious childA, B grade patients, especially childA grade patients have anti-fiber bloom effect. Used for inducing labor, oxytocin, renal insufficiency, treatment of treatment of mumps, pancreatitis, etc.

Prostaglandin E1 for injection is mainly suitable for myocardial infarction, heart failure, thromboangiitis, chronic arterial obliterans, central retinal vein thrombosis, for cardiopulmonary bypass to protect platelets, arteriography, vascular reconstruction surgery, etc.

Prostaglandin E1 Powder is a derivative of arachidene. It can significantly inhibit and relieve platelet agglutination, improve blood microcirculation, and directly act on vascular smooth muscle and dilate arterial vessels.

The half-life is as long as 5 ~ 10 minutes. It is clinically used for anticoagulation therapy in various types of angina pectoris, reducing the area of myocardial infarction, maintaining the open ductus arteriosum in infants, arterial and pulmonary hypertension, peripheral vascular diseases and other forms of CPB.

Prostaglandin E1 Powder Adverse reactions to prostaglandin:

It has an irritating effect on the veins, redness, swelling, heat, pain and other symptoms of irritation can occur, can cause phlebitis, should slow down the drip rate or temporarily stop the drug.

Prostaglandin E1 Powder  interactions:

Prostadil may potentiate the effects of antihypertensives, vasodilators and anticoagulants.

Prostaglandin E1 Powder of Expert Comment:

Prostadil belongs to the prostaglandin class of drugs. As it is an endogenous substance. Prostaglandin E1 can dilate blood vessels, improve peripheral circulation and prevent platelet aggregation. Therefore, it is clinically used in unstable angina, myocardial infarction, arterial occlusion, etc. However, there is a lack of a large number of clinical trials to confirm. The author believes that peripheral vascular diseases such as occlusive atherosclerosis, cerebral infarction, etc. can be tried prostaglandin.