Natural Isosorbide dinitrate Raw Powder bulk supplier

CAS: 87-33-2

MF: C6H8N2O8

MW: 236.14

EINECS: 201-740-9

Specification​: 99% min Isosorbide dinitrate Powder

Sample: Isosorbide dinitrate Powder Avaliable

Packaging: 1kg/bag, 25kg/drum

Brand: Ausreson

MOQ: 1 kg

Appearance: White powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Last updated: March 2026

Isosorbide dinitrate Powder Usage and Synthesis.

Studies on the mechanism of action of nitrate also indicate that its mechanism of action against angina is complex, in general the mechanism of action of isosorbide nitrate against angina has the following aspects:

(1) Reduce myocardial oxygen consumption. Nitrate dilates the venous blood vessels, increases the venous volume, thus reducing the volume of return blood, heart volume decreases, myocardial wall tension decreases, and ejection time is shortened; in addition, the arterial vasculature is diastasised, and the left ventricular afterload is reduced, thus achieving the purpose of lowering myocardial oxygen consumption.

(2) Myocardial blood flow redistribution, which is conducive to the perfusion of the ischemic area. Nitrate selectively expands large coronary transport vessels, increasing the flow in the ischemic area; reduces left ventricular filling pressure, increases endocardial blood supply, and improves left ventricular compliance; it also stimulates the generation of collateral branches, opening up the existing collateral branches and increasing the nutrient blood flow to perfuse the ischemic area.

(3) In atherosclerosis or acute ischemia, endothelial cells are unable to release NO and PGI; however, they accelerate platelet aggregation and the release of contractile substances from vascular endothelial cells. Exogenous nitrate can supplement the deficiency of endogenous NO and also promote the release of PGI. Nitrate itself has significant anti-platelet aggregation and anti-thrombosis effects.

NO is known to be an important biomessenger and effector molecule, and nitrate is one of the NO donor drugs.

Applications of Isosorbide dinitrate.

In the US and EU geriatric care sectors, ISDN is a first-line therapy for the long-term prevention of angina. It is frequently formulated into sustained-release tablets to provide 24-hour coverage for patients with coronary artery disease.

A major trend in North American cardiology is the combination of Isosorbide Dinitrate with Hydralazine. This dual-action therapy has shown significant benefits in improving survival rates and reducing hospitalizations for specific patient demographics with heart failure.

Due to its rapid absorption profile when formulated sublingually, ISDN is a vital component of "Rescue" medications used to terminate acute anginal attacks quickly.

Quality, Safety, and Regulatory Compliance

To secure high-value B2B contracts, technical transparency and safety documentation are paramount:

• USP/EP/BP Grade Compliance: Our powder meets the rigorous monographs of the United States, European, and British Pharmacopoeias, ensuring a minimum assay of  ≥99% (on a pure basis).

• Diluted Specifications (Safety First): Pure Isosorbide Dinitrate is an explosive hazard. We provide it as a Diluted Mixture (typically $20\%$, $40\%$, or $60\%$ with Lactose, Mannitol, or Starch) to ensure safe handling, transport, and manufacturing, compliant with RoHS and REACH safety protocols.

• Controlled Impurity Profile: Strictly monitored for related substances (like Isosorbide Mononitrate) to ensure the highest therapeutic index.

• Full Regulatory Support: Provided with CEP/COS, US DMF, GMP Certification, and COA for seamless international registration and export.

Preparation of Bulk Isosorbide dinitrate Powder.

Sorbitol solution is obtained by dehydration cyclisation and esterification with nitric acid. Specifically as follows: in the reaction bottle equipped with a stirrer, thermometer, add 50g of fuming nitric acid, concentrated sulfuric acid 7.5g, cooled to 10 ℃ with stirring, slowly added by dehydrated sorbitol 10g of solid and 1mL of water microthermal dissolution of the liquid obtained by keeping the reaction liquid temperature at 10 ~ 15 ℃, add the reaction reaction of the heat insulation reaction for 2h. Stirring will be poured into the reaction of 7 times the amount of iced water, stirring fully precipitated crystals.

[...]  Filtering, washing to neutral, drying, the crude product. Add the crude product into 1.5 times the amount of 95% ethanol, heat to dissolve, activated carbon decolourization reflux for 30min, while hot filtration, cooled to below 10 ℃, filtration precipitation of crystals, ethanol washing, low temperature drying, isosorbide nitrate, yield 70%.

Frequently Asked Questions (FAQ)

In 2026, we clarify: Isosorbide Dinitrate (ISDN) has a faster onset and is often used for acute relief (sublingual), but it undergoes significant first-pass metabolism. Isosorbide Mononitrate (ISMN) has 100% bioavailability and is used primarily for long-term, once-daily prophylaxis.

To maintain efficacy in 2026, doctors recommend a "Nitrate-Free Interval" of 10–14 hours per day (usually at night). This allows the vascular receptors to "reset," preventing the body from becoming desensitized to the drug.

Yes. In 2026, ISDN is frequently combined with Hydralazine (BiDil protocol) to treat heart failure, particularly in specific genetic populations, by reducing the heart's workload through simultaneous arterial and venous dilation.

Pharmaceutical-grade ISDN powder is intended for use by Licensed Manufacturers and Compounding Pharmacists. Due to its potency and explosive potential in pure concentrated form (if not diluted with lactose or other carriers), it must be handled according to strict safety protocols.

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