Clotrimazole Raw material Clotrimazole powder

Clotrimazole Raw material Clotrimazole powder

CAS:23593-75-1

MF:C22H17ClN2

MW:344.84

EINECS:245-764-8

Specification: 99% min Clotrimazole powder

Sample:Clotrimazole powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Clotrimazole powder Usage and Synthesis.

Clotrimazole is a synthetic pyrrole antifungal drug, which has an inhibitory effect on a variety of pathogenic fungi, and can also have a bactericidal effect when the concentration is high.

Clotrimazole can inhibit the biosynthesis of sterols such as ergosterol by interfering with the activity of cytochrome P450; damage the fungal cell membrane and change its permeability, resulting in the leakage of important intracellular substances; and also inhibit the biosynthesis of glycerol triglyceride and phospholipids in fungi;

It can also inhibit the biosynthesis of triglyceride and phospholipid. It can also inhibit the activity of oxidative and peroxidative enzymes, causing excessive accumulation of peroxides in the cell, resulting in the degeneration and necrosis of fungal subcellular structure.

Clotrimazole has broad-spectrum antifungal activity, has good antibacterial effect on S. epidermidis, S. trichinis, S. flexneri, S. coli, Cryptococcus spp. and Candida spp. It also has certain antibacterial activity on Schenk's spore filamentous fungi, Dermatophytes, Coccidioides vulgaris, and Histoplasma capsulatum.

Uses of Clotrimazole powder.

Broad-spectrum antifungal. Used for systemic fungal infections, also used topically for localised fungal infections.

(1)By reducing the activity of cytochrome P450, thus inhibiting the biosynthesis of sterols such as ergosterol in fungal cell membranes, damaging fungal cell membranes and changing their permeability, causing leakage of important intracellular substances.

(2)Clotrimazole can also inhibit the biosynthesis of triacylglycerol and phospholipids in fungi.

(3)It can also inhibit the activity of oxidase and peroxidase, leading to excessive accumulation of hydrogen peroxide in the cell, causing fungal subcellular structural degeneration and cell necrosis.

(4)Inhibits the transformation of Candida albicans from spores to invasive hyphae.

Pharmacological effect of Clotrimazole powder.

Clotrimazole can inhibit the cytochrome P4503A4-mediated metabolism of sirolimus, dofetilide and other drugs, so that the blood concentration of these drugs increased; with tacrolimus, trimethoprim, etc., can slow down the metabolism of these drugs and increase their toxicity;

Clotrimazole and betamethasone, can make the skin susceptible to infection or increase the opportunity for microbial reproduction, the possible mechanism is the inhibition of local inflammatory response; with mycobactericin, amphotericin B and flucytosine, Candida albicans has no synergistic antibacterial effect; and with amphotericin B in the combination of pharmacodynamic antagonistic effect.

In vivo and in vitro clotrimazole on Candida, Cryptococcus, Aspergillus, Algae, dermatophytes and so on have good bacteriostatic effect, the efficacy of superficial skin fungal disease is similar to ashwagandha, the efficacy of the deep fungal disease is similar to amphotericin B, the visceral pathogenic fungi, such as Candida albicans, Cryptococcus neoformans, coccus spores, and histopathogenic fungi, have good effect, the role of Candida albicans is stronger than that of the bacteriostatic mycophenolic fungi. It has good effect on Candida albicans than mycotoxin. Fungus is not easy to produce drug resistance to this product.

It is easily absorbed internally and can be used internally for the treatment of systemic and deep fungal infections such as Aspergillus fumigatus, Candida albicans, Cryptococcosis, Coccidioidomycosis, Histoplasmosis (dogs, cats) and fungal septicaemia. For serious deep fungal infections, it should be used in combination with amphotericin B.

External use can also be used to treat superficial fungal infections, such as ringworm and livestock ringworm, ringworm, etc.. It is not effective for ringworm of the head. Clotrimazole is also effective against certain gram-positive bacteria and trichomonas vaginalis.

Product method of Bulk Clotrimazole powder.

It is obtained from o-chlorobenzoic acid by esterification, addition, hydrolysis, chlorination and condensation. It can also be obtained from o-chlorotoluene by chlorination to o-chlorotrichlorobenzene, then condensed with benzene in the presence of aluminium trichloride to produce diphenyl-(2-chlorophenyl)chloromethane, and finally condensed with imidazole to obtain clotrimazole.