Arctiin Raw Materials Arctiin Powder

CAS:20362-31-6

MF:C27H34O11

MW:534.55

EINECS:/

Specification​: 99% min Arctiin Powder

Sample:Arctiin Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:White

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Arctiin Usage and Synthesis.

Burdock glycoside is a bioactive molecule derived from the traditional Chinese medicine burdock, which has a variety of pharmacological effects. Studies have shown that burdock glucoside has powerful antioxidant properties and can regulate redox balance, which is potentially useful in the treatment of diseases such as osteoarthritis.

In addition, burdock glycosides have a variety of antibacterial, antiviral, anti-aging and anticancer effects. For example, burdock is rich in polyynes that are the material basis for antibacterial and antifungal effects, and burdock glycosides can induce the production of antibiotics in the body, which in turn produce antiviral effects.

At the same time, burdock glycosides can also significantly scavenge free radicals and antioxidants, and can reduce cell damage and remove deposited aging metabolites, and play an anti-aging role.

In addition, polyphenols such as caffeic acid, chlorogenic acid, and isochlorogenic acid in burdock glycosides have anticancer and antimutagenic effects.

Uses of Arctiin.

It has anti-pancreatic cancer activity, one of its mechanism of action is to induce apoptosis. It can cause vasodilatation, blood pressure drop; cause cold-blooded and warm-blooded animals

to have convulsions, cause respiratory failure in large doses, and cause reddening of the skin and diarrhoea in mice, and inhibit the intestines and uterus of isolated rabbits. It has a

paralysing effect on motor nerves and bones, and can cause a mild tail-lifting reaction in mice.

Firstly, burdock glycosides have obvious calcium antagonism, inhibit contraction caused by high potassium, and also have antihypertensive effects.

Secondly, burdock glucoside has a certain improvement effect on nephropathy, can inhibit the increase of urinary protein excretion, and can improve the serum biochemical indicators.

In addition, burdock glucoside also has anti-tumour anti-mutagenic effect, isolated a relative molecular mass of more than 300,000 above the anti-mutagenic factor .

In traditional Chinese medicine, burdock seed (the seed of burdock) is used for laxative purposes, and its mechanism mainly involves lubricating the intestines and lowering lung qi.

Pharmacological Effect of Arctiin.

Burdock glucoside is a major active substance in burdock, its content in burdock up to 8.4%, the Chinese Pharmacopoeia (2005 edition) burdock under the provisions of burdock, burdock

glucoside content should be more than 5% of the quality of the herb. Pharmacological studies have shown that burdock glucoside has significant anti-tumour, anti-virus, anti-oxidation and

other physiological activities, has attracted widespread attention.

As the content of burdock glucoside is much higher than that of burdock seed, another active ingredient in burdock seed, burdock sapogenins, people also use chemical hydrolysis and biotransformation methods to convert burdock sapogenins into the desired active substances.

Therefore, burdock glucoside is also an important raw material for medicines in addition to its own medicinal utilisation value.

In vitro studies of Bulk Arctiin Powder.

Arctiin induces growth inhibition and dephosphorylates the tumour suppressor rb protein (retinoblastoma-forming protein) in human immortalised keratinocytes HaCaT. arctiin inhibits cell growth by down-regulating cyclinD1 protein levels. arctiin-induced inhibition of cyclinD1 protein expression is present in a variety of human tumour cells, including osteosarcoma ,lung, colon, cervical, melanoma, transformed renal cells and prostate cancer.