Raw materials Glycyrrhetinic Acid Powder

CAS:471-53-4

MF:C30H46O4

MW:470.69

EINECS:207-444-6

Specification: 99% min Glycyrrhetinic Acid Powder

Sample:Glycyrrhetinic Acid Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:White

Storage: Store at -20°C

Shelf Life: 2 Years

Test Method: HPLC

Glycyrrhetinic Acid Powder Usage and Synthesis.

Glycyrrhizic hypochlorous acid is a compound with a variety of biological activities, and its main effects include anti-inflammatory, immunomodulatory, antibacterial and anti-inflammatory,

antioxidant, anti-aging and whitening.

In cosmetics, glycyrrhizic hypochlorous acid, as an important skin conditioning agent, can regulate the immune function of the skin, enhance the skin's resistance to disease, eliminate inflammation, prevent allergies, clean the skin, and relieve the skin of the toxic effects of the relevant ingredients in cosmetics and other external factors.

At the same time, licorice hypochlorous acid can also effectively inhibit the activation of tyrosinase, prevent the production of melanin, with whitening effect. In addition, liquorice

hypochlorous acid is also used to treat some diseases, such as acute inflammation and acute serum sickness.

It was also found that glycyrrhizic hypochlorous acid could modify enzyme-sensitive doxorubicin liposomes to improve the efficacy of the drug and reduce toxic side effects.

Uses of Glycyrrhetinic Acid.

Sweetener; sweetness improver; flavouring agent (with the application of salt, the effect is particularly large); aroma enhancer (dairy products, cocoa products, egg products, mutton, etc.

in addition to nasty aroma). Our folk customarily used in sauce and sauce products, pickles, etc.

Glycyrrhizic hypochlorous acid is an important cosmetic raw material, mainly used as a skin conditioner.

It is anti-inflammatory and anti-allergic, inhibits bacterial reproduction, etc. It can be used in cosmetics to regulate the skin's immune function, enhance the skin's disease-resistant ability,

eliminate inflammation, prevent allergies and clean the skin. In addition, liquorice hypochlorous acid can also lift the toxic side effects of relevant ingredients in cosmetics and other external

factors on the skin.

Licorice hypochlorous acid is also a classic anti-inflammatory drug, which can effectively inhibit the activation of tyrosinase and prevent the production of melanin, with whitening effect. In the

daily chemical industry, the application of glycyrrhizic hypochlorous acid can also play the role of antibacterial and anti-inflammatory, antioxidant, anti-aging, absorbing ultraviolet rays,

whitening and brightening the skin, and eliminating blemishes.

In addition, glycyrrhizic acid has an inhibitory effect on a variety of acute inflammation, and its anti-inflammatory effect does not depend on the pituitary-adrenocortical system, but with the

inhibition of inflammation in the tissue of the generation of PgE2, antagonism of inflammatory mediators, histamine, 5 hydroxytryptophan and other effects.

Glycyrrhizic acid also has the effect of enhancing the body's non-specific cellular immune function.

In addition, glycyrrhizic hypochlorous acid is one of the main active components of liquorice,which has various medicinal values.

It has been found that glycyrrhizic acid and glycyrrhizinic acid have inhibitory effects on a variety of cancers, such as liver cancer, lung cancer, breast cancer, etc., and can also be combined with chemotherapeutic drugs to increase the efficacy of the drugs, and at the same time, it can be developed to be used as a carrier material for drug delivery in order to solve the problems of low water-solubility, low bioavailability, and high toxicity and side-effects of the drugs.

Chemical Properties of Glycyrrhetinic Acid.

Glycoside consisting of glycyrrhetinic acid-ff two molecules of glucuronic acid. White crystalline powder, sweet taste, sweetness is about 200 times that of sucrose. Its sweetness is different

from that of sucrose and other sweeteners, and it takes a few moments for the sweetness to be felt in the mouth, but the retention time is long.

A small amount of liquorice glycoside and sucrose can be used with 20% less sucrose and the sweetness remains unchanged. Although there is no aroma, but it has the effect of increasing

the fragrance. Melting point (decomposition) 220℃. Aqueous solution is weakly acidic, can be by the action of acid.

Product Method of Bulk Glycyrrhetinic Acid Powder.

Extracted from the rhizomes of the leguminous plant Glycyrrhizauralen-sisfisch (Glycyrrhizauralen-sisfisch) glycyrrhizic acid, made into an ammonium salt and then hydrolysed and obtained. Licorice is my annual herb, mainly produced in Inner Mongolia and Gansu and other places.

The roots and rhizomes of liquorice mainly contain glycyrrhizin, the potassium and calcium salts of glycyrrhizic acid (Glycyrrhiz-icacid), which is the sweet component of liquorice. The

sweetness is about 50 times that of sucrose. The crushed liquorice is heated with water,continuously extracted in countercurrent, separated to remove the dregs impurities, and an aqueous solution is obtained. Evaporation, concentration, stirring with sulphuric acid pH 2-3.static precipitation, remove the supernatant. Precipitate with water to wash out the sulfate,

heating and concentration concentration, boiled into glycyrrhizic acid paste.

The glycyrrhizic acid paste is crushed, and extracted with 95% ethanol plus flow 2-3 times, each time 3h, to get ethanol solution. After filtering and stirring through the ammonia to pH 7-7.5.

and then filtered, the glycyrrhizic acid triammonium salt crude, refined with glacial acetic acid,that is, beige coloured glycyrrhizic acid monoammonium salt.

The monoammonium salt of glycyrrhizic acid was added into 5% aqueous sulfuric acid solution,stirred and heated to near boiling, reflux hydrolysis for 15h, filtered, washed with water to

obtain glycyrrhizic acid crude product. After recrystallisation and decolourisation, the content of more than 92% of glycyrrhizic acid was obtained. The total yield was about 0.5% in terms of

liquorice.