Aminoguanidine HCl Raw Materials Aminoguanidine HCl powder

CAS:1937-19-5

MF:CH7ClN4

MW:110.54608

EINECS:217-707-7

Specification​: 99% min Aminoguanidine HCl powder

Sample:Aminoguanidine HCl powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Aminoguanidine HCl powder Usage and Synthesis.

Aminoguanidine hydrochloride also has applications in the medical field, for example, it can be used to treat diabetic complications. In addition, arginine hydrochloride is also a commonly used drug, which can participate in the ornithine cycle in the body and promote urea production to reduce blood ammonia, which is effective for surgical burns, hyperammonaemia due to hepatic insufficiency and hepatic encephalopathy patients.

At the same time, arginine hydrochloride is also the main component of sperm protein, oral administration can increase the number and motility of sperm, and thus used in male infertility.

Uses and functions of Aminoguanidine HCl powder.

Aminoguanidine hydrochloride is a pharmaceutical intermediate and organic synthesis intermediate, which can be prepared from aminoguanidine carbonate, and can be used in the preparation of soyabean glycoside derivatives and in organic synthesis in the laboratory.

Preparation of Aminoguanidine HCl powder.

Preparation of aminoguanidine hydrochloride: weigh 9g of aminoguanidine carbonate in a 250ml three-necked flask, add 20ml of anhydrous ethanol, the solid is insoluble in anhydrous ethanol, the formation of a suspension, room temperature stirring dropwise addition of 30% of the mixture of concentrated hydrochloric acid 6 ml and 10 ml of anhydrous ethanol, until no longer produce bubbles, and then continue to stir the reaction at room temperature for 1 hour.

The resulting suspension was heated to make the solids completely dissolved, naturally reduced to room temperature, moved to the refrigerator, placed overnight, obtained white rod-shaped crystals, melting point of 166-167 ℃.

In vivo studies of Bulk Aminoguanidine HCl powder.

Aminoguanidine ameliorates de novo hypoxic-ischemic brain injury, and the temporal distribution of NO correlates with the neuroprotective effects of aminoguanidine.

AG exerts its neuroprotective effects by inhibiting NO production by iNOS during reoxygenation after the end stage of hypoxia.The half-life of aminoguanidine in vivo is approximately 6-8 hours, or about 4.4 hours in humans with normal renal function.

Aminoguanidine is also an inhibitor of late glycosylation end product formation. Treatment of adult rats with late glycosylation end-product-modified BSA increases the area of cerebral infarction, which is attenuated by Aminoguanidine.