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  • Vincamine Raw Materials Vincamine Powder

    • Vincamine Raw Materials Vincamine Powder
    • Vincamine Raw Materials Vincamine Powder storehouse
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    Product Overview:

    Vincamine is one of the major alkaloids in V. minor, it is a monoterpene indole alkaloid in the class of albizia alkaloids, its chemical name is (3α,14β,16α)-14,15-dihydro-14-hydroxyvincamine-14-carboxylic acid methyl ester, white powder, can be soluble in acidic solution.1953, Schlittle and Furlenmeier isolated Vincamine from V. minor in Chemicalbook.1962, Trojanek, Mokry, Clauder et al. determined its chemical structure.1968, Trojanek and Furlenmeier et al. determined its chemical structure.1962, Trojanek, Mokry, Clauder and others. Furlenmeier isolated Vincamine from V. minor.In 1962, Trojanek, Mokry, Clauder et al. determined its chemical structure.

    Vincamine Raw Materials Vincamine Powder Attributes

    Vincamine Raw Materials Vincamine Powder

    CAS:1617-90-9

    MF:C21H26N2O3

    Vincamine

    MW:354.44

    EINECS:216-576-3

    Specification: 99% min Vincamine Powder

    Sample:Vincamine powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance:White

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Vincamine Raw Materials Vincamine Powder Details

    Vincamine Powder Usage and Synthesis.

    The mechanisms of Vincamine in the treatment of ischemic cerebrovascular disease include: increasing the oxygen and glucose utilisation of brain tissue; dilating cerebral blood vessels and improving microcirculation; blocking slow calcium and voltage-gated sodium channels; antioxidant; and protecting neurological function.

    Although the above basic research is relatively complete, the evidence-based basis for the clinical application of Vincamine in ischemic cerebrovascular disease is slightly insufficient, and it is necessary to further explore its clinical efficacy and its precise mechanism of action in randomised, large-sample, multi-centre clinical trials.

    Vincamine powder

    Uses and functions of Vincamine.

    For cerebral vascular sclerosis, cerebral insufficiency and vascular diseases of the eyes, ears, nose and throat. It is especially indicated for early manifestations of progressive cerebral insufficiency such as vertigo, headache, memory loss, fatigue, and poor concentration.

    It can also be used for cerebral degeneration and its symptoms such as anxiety, aggressiveness, stress, motor difficulties, slow thinking, senile irritability and sphincter disorders, as well as acute manifestations and sequelae of craniocerebral injuries, such as post-injury coma, impaired consciousness, hemiplegia (hemiplegia), speech disorders, conscious symptoms of brain injury and arterial disease dementia.

    In addition, it is also effective in retinal vascular sclerosis, cochlear disorders caused by blood vessels such as dizziness and Meniere's syndrome.

    Vincamine

    Pharmacological effect of Vincamine.

    Vincamine can cross the blood-brain barrier, so that the lesion area brain tissue to maintain and restore the oxidative catabolism of glucose metabolism, so that the production of lactic acid and carbon dioxide release back to normal, so as to dilate the cerebral small blood vessels, improve cerebral circulation; on the normal brain tissue, as well as the patient's brain tissue of the normal brain area of the blood flow does not have a significant effect on the systemic circulation; in addition to the effect of a slight sedation.

    Vincamine Raw

    Preparation method of Bulk Vincamine Powder.

    A method for the preparation of perponine, said method comprising the following steps:

    1) Preparation of itponine: in petroleum ether, using concentrated ammonia to free itponine hydrochloride, and then add acid salt solution to remove the remaining ammonia, after the completion of the reaction, the liquid is divided, the aqueous layer is extracted with petroleum ether, and the organic phases are combined, and the organic phases are dried with a desiccant and filtered, and the filtrate is obtained from itponine by distillation under reduced pressure;

    2) the preparation of Vincamine: it will be obtained in step (1) to add organic solvents to dissolve it, add Pd/C under stirring, hydrogen atmosphere as well as atmospheric pressure, a certain temperature for the reaction, TLC to monitor the end point of the reaction, filtration, the filtrate is obtained after distillation under reduced pressure Vincamine;

    3) Preparation of monoperoxymaleic acid: in N,N-dimethylformamide, add maleic anhydride to dissolve, drop 30% hydrogen peroxide, drop after the reaction, the reaction is complete, cool down, dilute with cold methanol standby;

    4) the preparation of Vincamine: the Vincamine obtained in step (2) is added to methanol to dissolve, after cooling down, add a certain amount of monoperoxymaleic acid obtained in step (3) dropwise, oxidation reaction for a period of time, and then add a certain amount of monoperoxymaleic acid dropwise, dropwise continue to carry out the oxidation reaction for a period of time, the reaction is complete, dropwise add the reductant solution to the starch KI paper no longer discolouration, warming up to rearrangement of the reaction, reaction After the completion of the reaction down to 20-30 ℃, add a certain amount of water and concentrated ammonia to adjust the pH to a certain range, cooling precipitation, filtration, filtering, the filter cake by methanol and water washing, and then at a certain temperature, water slurry, filtration, filter cake drying under reduced pressure to obtain periwinkle amine.

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