Icariin Raw Materials Icariin Powder

CAS:489-32-7

MF:C33H40O15

MW:676.66

EINECS:610-440-0

Specification: 99% min Icariin

Sample:Icariin Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:Yellow

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Icariin Powder Usage and Synthesis.

Epimedoside, as one of the active ingredients of Horny Goat Weed, a key medicine for tonifying the kidney and aiding yang, can promote the function of the reproductive system.

Icariin can inhibit ferrous sulfate/hydrogen peroxide-induced oxidative stress injury in human spermatozoa, activate ERK1 /2 signaling pathway, promote proliferation of trophoblast Sertoli's in testis, and enhance the male reproductive function; it can regulate hypothalamus-pituitary-gonadal axis, up-regulate the expression of dopamine and 5-hydroxytryptophan in the hypothalamus, activate the PI3K/AKT /eNOS /NO signaling pathway, and increase the NO , serum testosterone concentration, shorten capture latency and ejaculation latency, increase capture and ejaculation rate as well as testicular and prostate indices, and improve the sexual function of male mice; it can activate NO-cyclic guanosine monophosphate signaling pathway, inhibit the expression of phosphodiesterase type 5, and improve erectile dysfunction.

Uses of Icariin.

Epimedium Glycoside has the effect of increasing cardiovascular and cerebrovascular blood flow, promoting hematopoietic function, immune function and bone metabolism, tonifying the kidney and aphrodisiac, anti-aging, anti-tumor and so on.

1, the role of the endocrine: Epimedium glycosides can promote sexual function is due to hypersecretion of semen, seminal vesicles filled, stimulate the sensory nerves, and indirectly stimulate the libido and cause.

2, on the immune system function: kidney deficiency patients T cell number, gonorrhea rate, antibodies, antigens and reticuloendothelial system phagocytosis function is low, and after epimedium and other kidney tonic medicine treatment can be improved.

3, anti-aging effect: Epimedium can affect the aging mechanism from different aspects. Such as affecting cell reproduction, prolonging the growth period, regulating the immune and secretion system, improving the body metabolism and organ function.

Pharmacological effect of Icariin.

1. Effects on sexual function Epimedium extract has a certain effect of promoting gonadal function. Flavonoid components such as Epimedium Glycoside has the effect of tonifying the kidney and aphrodisiac, 30 to 1000μg/l can promote the secretion of estradiol by follicular granulosa cells, in 1000μg/l can promote the secretion of corticosterone by adrenal cortical cells. At the same time, EPS can increase the level of gonadal hormones, mainly increase the level of FSH.

2. Improve the immune function of the body, Epimedium brevicornum 50% methanol extract can inhibit the transformation of lymphocytes. The total flavonoids of Epimedium can make the "Yang deficiency" mice form high cell function and antibody, and obviously enhance the human T cell immune function.EPS and EI have immunomodulatory effects.

3. Antioxidant EPS and EI have antioxidant activity can enhance the activity of antioxidant enzymes, reduce the role of free radical products.

4. Anti-aging effects Epimedium extract can affect cell reproduction, prolong the growth period, regulate the immune and secretion system, improve the body metabolism and the function of various organs and anti-aging and prolong life.

5. Cardiovascular effects of Epimedium alcohol extract of the non-amino acid part can significantly increase the coronary flow of isolated rabbit heart. Decoction and alcohol infusion have hypotensive effect. Epimedium glycoside can directly relax vascular smooth muscle, can dilate coronary artery, femoral artery and cerebral artery.

The mechanism of action is to inhibit the effect of extracellular calcium ion inward flow in vascular smooth muscle.

Product Method of Bulk Icariin Powder.