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Berberine Hydrochloride Powder CAS 633-65-8
Product Overview:
Berberine Hydrochloride, also known as Berberine Hydrochloride, has long been used in clinical practice as a purgative, detoxifying and antibacterial drug. It is commonly used in the treatment of bacillary dysentery, acute gastroenteritis, chronic cholecystitis, conjunctivitis, purulent otitis media and other diseases, and has significant efficacy. Berberine hydrochloride is an isoquinoline alkaloid found in many plants of 10 genera in 4 families, including the Berberidaceae. Berberine can be precipitated from ether as yellow needle-like crystals. Berberine is a quaternary ammonium alkaloid, and its salts all have a relatively small solubility in water, for example, 1:500 for hydrochloride and 1:30 for sulfate.
Berberine Hydrochloride Powder CAS 633-65-8 Attributes
CAS:633-65-8
MF:C20H18ClNO4
MW:371.81
EINECS:211-195-9
Specification: 99% min Berberine Hydrochloride Powder
Sample:Berberine Hydrochloride Powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance:Yellow
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Berberine Hydrochloride Powder CAS 633-65-8 Details
Berberine Hydrochloride Powder Usage and Synthesis.
Berberine has antibacterial effect on hemolytic streptococcus, staphylococcus aureus, gonococcus and Fuchs' and Shigella dysentery bacillus, and enhances phagocytosis of white blood cells.
Berberine hydrochloride (commonly known as berberine hydrochloride) has been widely used in the treatment of gastroenteritis, bacillary dysentery, etc. It is also effective against tuberculosis, scarlet fever, acute tonsillitis and respiratory tract infections.
Berberine Hydrochloride has an inhibitory effect on dysentery bacillus, Escherichia coli, Diplococcus pneumoniae, Staphylococcus aureus, Streptococcus pyogenes, S. typhi, and amoeba protozoa. It is mainly used clinically for intestinal infections and bacillary dysentery.
It is also found to have antiarrhythmic effect. Berberine has strong in vitro and ex vivo anti-tumor activity and can induce B16 cell differentiation; with cytarabine hydrochloride in vitro has a synergistic effect.
Uses of Berberine Hydrochloride.
Berberine hydrochloride tablets are an over-the-counter medication that is used to treat intestinal infections, such as gastroenteritis. It contains berberine hydrochloride, which is a kind of flavonoid that has several effects.
Firstly, it has anti-infective effects, inhibiting a variety of bacteria, especially Shigella spp. and S. typhi, which have stronger inhibitory effects.
Secondly, Berberine Hydrochloride Tablets has the effect of lowering blood lipids, which can reduce blood lipids through gene transcription regulation.
In addition, it can treat diabetes mellitus, which is achieved by reducing body weight and improving glucose tolerance in mice.
Finally, berberine hydrochloride tablets also have some anti-arrhythmic effects. Adverse effects of oral berberine hydrochloride tablets are rare, with occasional nausea, vomiting, skin rash and medicinal fever, which disappear after stopping the drug.
Pharmacological effect of Berberine Hydrochloride.
Wide antimicrobial spectrum, in vitro on a variety of Gram-positive and negative bacteria are bacteriostatic, including hemolytic streptococcus, aureus, Vibrio cholerae.
Meningococcus, Shigella dysentery bacillus, typhoid fever bacillus, diphtheria bacillus, etc. It has strong inhibitory effect, inhibiting bacteria at low concentration and killing bacteria at high concentration.
It also has a certain inhibitory effect on influenza virus, amoeba, leptospirosis, and certain skin fungi. In vitro experiments have confirmed that safranin can enhance the phagocytosis of leukocytes and hepatic reticuloendothelial system.
Dysentery bacillus, hemolytic streptococcus, aureus and so on are very easy to produce drug resistance to this product. There is no cross-resistance with penicillin and streptomycin.
Product Method of Bulk Berberine Hydrochloride Powder.
It is obtained by crushing the ten great gonglao or three needles and extracting them with sulfuric acid, precipitating the crude product with hydrochloric acid, and then refining it.
