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Camptothecin Raw Materials powder Camptothecin
Product Overview:
Camptothecin is an alkaloid extracted from the seeds or root bark of the deciduous plant Camptotheca acuminata of the Davidiaceae family. It can directly destroy the DNA structure and bind to DNA, making DNA vulnerable to endonuclease attack. It also inhibits DNA polymerase and affects DNA replication. It is mainly sensitive to proliferating cells and is a cell cycle-specific drug that acts in the S phase and has a slight killing effect on G1, G2 and M phase cells.
Camptothecin Raw Materials powder Camptothecin Attributes
CAS:7689-03-4
MF:C20H16N2O4
MW:348.35
EINECS:444-280-6
Specification: 99% min Camptothecin powder
Sample:Camptothecin powder
Packaging:1kg/bag, 25kg/drum
Brand:Raw Materials
Appearance:yellow
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Camptothecin Raw Materials powder Camptothecin Details
Camptothecin powder Usage and Synthesis.
Camptothecin is mainly used for digestive tract tumors. It has good efficacy for gastric cancer, rectal and colon cancer, and can increase the chance of surgical resection of advanced gastric cancer.
It has certain efficacy for cylindrical adenocarcinoma of the head and neck, bladder cancer and lung adenocarcinoma. It can shrink tumors for primary liver cancer. Intravenous injection of camptothecin emulsion can increase the chance of surgical resection of liver cancer. It is also effective for malignant hydatidiform mole and choriocarcinoma. Antitumor alkaloid.
It binds irreversibly to the DNA-topoisomerase I complex, inhibits the rebinding of DNA after topoisomerase I cleavage, and forms a covalent connection between the enzyme and DNA. A cytotoxic antitumor drug.
Uses of Camptothecin powder.
Camptothecin binds irreversibly to the DNA topoisomerase I complex, affecting the cell cycle process and can be used as an anticancer drug. It is used for gastric cancer, colon cancer, rectal cancer, head and neck cylindroma cancer and bladder cancer.
It is used to treat gastric cancer, intestinal cancer, chronic myeloid and acute leukemia, etc.
Pharmacological effect of Camptothecin powder.
Product Method of Bulk Camptothecin powder.
This product is an alkaloid extracted from the root, bark and fruit of the plant Eclipta genus of the Davidiaceae family. It can also be produced synthetically. Soak the crude powder of the fruit of the tree of life in 10 times the amount of 80% ethanol for 24 hours, collect the percolation liquid, and concentrate under reduced pressure to recover the ethanol.
The concentrate is allowed to stand to take the clear liquid, which is extracted with chloroform. The extract is distilled to recover the chloroform until dry, and then methanol solution is added. Cool and filter, and the filter cake is the crude product of camptothecin. The crude product is recrystallized with a methanol-chloroform mixed solvent to obtain camptothecin. For the herbal drug Camptothecin juice, the total yield is 0.03-0.04%.
