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  • Pharmaceutical Isotretinoin Raw Materials powder

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    Product Overview:

    Isotretinoic acid, an organic compound with the chemical formula C20H28O2, is used primarily as A keratolytic drug for acne vulgaris and keratosis disorders. Because it has the effects of shrinking sebaceous gland tissue, inhibiting sebaceous gland activity, reducing sebaceous gland secretion, alleviating epithelial cell keratosis and reducing the number of propionibacterium acnes, it is used in the treatment of concomitant acne, nodular cyst acne, fulminant acne and so on. Although isotretinoic acid is effective in the treatment of severe acne, it is also known for adverse reactions, such as skin mucosal adverse reactions.

    Pharmaceutical Isotretinoin Raw Materials powder Attributes

    Isotretinoin Raw Materials powder

    CAS:4759-48-2

    MF:C20H28O2

    Isotretinoin

    MW:300.44

    EINECS:225-296-0

    Specification: 99% min Isotretinoin

    Sample:Isotretinoin powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance:Yellow

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Pharmaceutical Isotretinoin Raw Materials powder Details

    Isotretinoin of Usage and Synthesis.

    1. Isotretinoic acid is the first choice drug for refractory acne, especially for patients with severe nodular, cystic and inflammatory acne who are ineffective in traditional treatment;

    2. Generalized flat wart or epidermoplasia verrucosum;

    3. Abnormal keratosis;

    4. Cutaneous lupus erythematosus;

    5. Lichen planus and lichen atrophicans.

    Isotretinoin powder

    Uses of Isotretinoin.

    It is A class of vitamin A drug, which has the function of inhibiting the proliferation and differentiation of skin gland cells strongly and quickly, and is effective for severe gangliform cystic acne. The gastrointestinal absorption of this product is good, but the local drug is ineffective. It can also be used for severe acne, cystic acne and gathering acne that are ineffective in the treatment of other drugs. It also has certain effect on skin diseases such as rosacea, ichthyosis, follicular keratosis and pityriasis rufuropilaris.

    Isotretinoin

    Pharmacological action of Isotretinoin.

    Isotretinoic acid belongs to the first generation of tretinoic acid and is A stereoisomer of all-trans tretinoic acid. Oral administration has anti-oil effect and has special effect on severe acne. The mechanism of action is as follows:

    ① It can shrink the sebaceous glands, inhibit the activity of sebaceous glands and reduce the secretion of sebaceous glands, thus inhibiting the reproduction of propionibacterium acnes that depends on the growth of lipid environment.

    ② It has the effect of anti-keratosis, inhibiting excessive proliferation and promoting differentiation of epidermal cells, and alleviating the keratosis of hair follicle orifice and sebaceous duct.

    ③ It can also affect the function of monocytes and lymphocytes, inhibit the chemotaxis of neutrophils and have anti-inflammatory activity.

    ④ It selectively binds to the nuclear receptor of retinoic acid to play A therapeutic role. It can inhibit the proliferation of Corynebacterium acne, and has immunostimulating effect at low dose and immunosuppressive effect at high dose.

    ⑤ can inhibit the formation of collagenase and gelatin enzyme in the skin, and can inhibit the activity of ornithine decarboxylase. Since the induction of ornithine decarboxylase plays A major role in skin mutation, isotretinoin can also inhibit the development of tumors.

    When used locally, the action mechanism of this product is similar to that of retinoic acid, which can induce epidermal cell proliferation, promote the differentiation of epidermal cell granule layer into stratum corneum, and regulate the abnormal keratosis process of hair follicle sebum epithelium, so as to play A therapeutic role.

    Isotretinoin raw

    Product method of Bulk Isotretinoin Powder.

    After reacting with ethyl magnesium chloride, β-ionone reacts with triphenylphosphine to form triphenyl ester salt, and then reacts with cyclopentenone derivatives to form isotretinoic acid and its 8Z isomer. The 8Z isomer was separated and isomerized to isotretinoic acid by palladium nitrate.

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