Pharmaceutical intermediates estradiol enanthate Raw powder supplier

CAS: 4956-37-0

MF: C25H36O3

MW: 384.56

EINECS: 225-599-8

Specification​: 99% min estradiol enanthate powder

Sample: estradiol enanthate powder Avaliable

Packaging: 1kg/bag, 25kg/drum

Brand: Ausreson

MOQ: 1 kg

Appearance: white powder

Shelf Life: 2 Years

Test Method: HPLC

Last updated: March 2026

estradiol enanthate Powder Usage and Synthesis.

Estradiol entanoate is clinically used for various symptoms caused by ovarian insufficiency or ovarian hormone deficiency, mainly functional uterine bleeding, primary amenorrhea, menopausal syndrome and prostate cancer.

• Extended Half-Life (7–10 Days): Unlike Estradiol Valerate (half-life of ~3-5 days), EEn powder provides a significantly flatter curve. In 2026, this is known as the "Stability Advantage," reducing mood swings and physical symptoms caused by rapid hormonal drops.

• Intramuscular/Subcutaneous Depot: When formulated into an oil-based carrier, EEn creates a lipophilic reservoir in the tissue. The body’s enzymes (esterases) slowly cleave the enanthate chain, releasing pure $17\beta-Estradiol$ into systemic circulation.

• Bone Density & Cardiovascular Support: In 2026, stable E2 levels are recognized as critical for maintaining bone mineral density and endothelial health in estrogen-deficient individuals.

• Minimal Liver Impact: By bypassing the "first-pass metabolism" of the liver (unlike oral pills), EEn powder in 2026 is favored for reducing the risk of SHBG spikes and blood clots.

Use of estradiol enanthate.

Estradiol entanoate is clinically used for various symptoms caused by ovarian insufficiency or ovarian hormone deficiency, mainly functional uterine bleeding, primary amenorrhea, menopausal syndrome and prostate cancer.

1. Micronization for Injectable Stability: In 2026, the particle size of EEn powder is critical. Micronized Estradiol Enanthate allows for easier dissolution in carrier oils (like Grape Seed or MCT oil) and prevents "crashing" or recrystallization in the vial.

2. Ultra-High Purity ($\geq$ 99.5%): For long-term HRT, zero impurities are non-negotiable. 2026's top-tier powders are HPLC-verified to ensure the absence of residual solvents or synthesis precursors that could cause injection site reactions.

3. Low-Melting Point Integrity: EEn has a relatively low melting point ($94-96°C$). Premium 2026 suppliers use Cold-Chain Logistics and vacuum-sealed packaging to prevent clumping and maintain the crystalline structure during transit.

The 2026 "Endo-Pure" Checklist

• ≥ 99.0% Purity (USP/EP Standards): Meeting the United States or European Pharmacopoeia benchmarks.

• Complete Impurity Profile: Disclosure of related substances (Total Impurities $<0.5\%$).

• Heavy Metal & Microbiological Testing: Essential for B2B procurement in the 2026 medical-grade compounding sector.

• BSE/TSE-Free: Verification that the synthesis is purely plant-derived (typically from Sterol fermentation).

Preparation of estradiol enanthate.

In the first step, estradiol was used as raw material to react with heptyl chloride under the catalysis of pyridine to obtain estradiester diheptylate.

In the second step, estradiester dienanthate in the first step is used as raw material, hydrolyzed in alcohol solvent under the action of base, and crude estradiol enanthate is obtained after post-treatment.

In the third step, estradiol enanthate in the second step is used as raw material and refined by methanol to obtain estradiol enanthate fine.

Frequently Asked Questions

In 2026, we categorize EV as "Short-Acting" and EEn as "Long-Acting." EEn requires fewer injections (typically once every 7–10 days) and results in much more stable blood levels, which is often preferred for long-term therapy.

For B2B compounding, EEn is often formulated at 10mg/mL to 40mg/mL. Clinical protocols in 2026 usually suggest 4mg to 8mg injected once a week to maintain optimal physiological levels.

While possible, EEn is specifically optimized for Oil-Based Injections due to its lipophilic ester chain. For water-based gels, pure Estradiol (Base) is typically preferred in 2026.

Side effects are generally related to dosage. In 2026, we emphasize that Stable Levels (provided by EEn) significantly reduce the risk of common E2 side effects like migraines or water retention compared to high-peak esters.

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