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Pharmaceutical intermediates powder Cefmenoxime raw material
Product Overview:
Cephaloxime is a semi-synthetic third-generation cephalosporin with an antibacterial profile similar to cefotaxime, and has antibacterial effects on G- and G+ aerobic and anaerobic bacteria. Among G-bacteria, the antibacterial activity against Escherichia coli and pneumobacter was slightly stronger than that of cefotiam, and obviously stronger than that of the first generation of cefzolin. Influenzae, Proteus, Serratia marcescens, Citrobacter and Enterobacter were also stronger than cefotiam and stronger than cefazoline. It also has a strong effect on Bacteroides
Pharmaceutical intermediates powder Cefmenoxime raw material Attributes
CAS:65085-01-0
MF:C16H17N9O5S3
MW:511.56
EINECS:278-299-4
Specification: 99% min Cefmenoxime Powder
Sample:Cefmenoxime Powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance:white
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Pharmaceutical intermediates powder Cefmenoxime raw material Details
Cefmenoxime powder Usage and Synthesis.
Ceftoxime is applicable to the following infections caused by ceftoxime sensitive streptococcus (except enterococcus), Streptococcus pneumoniae, Peptococcus, Peptostreptococcus, Escherichia coli, Citrobacter, Klebsiella, Enterobacter, Serratia, Proteobacteria, Haemophilus influenzae, Bacteroides, etc. :
1. Secondary infection of pneumonia, bronchitis, bronchiectasis and chronic respiratory diseases; Lung abscess, empyema;
2, pyelonephritis, cystitis; Bartyloadenitis, endometritis, adnexitis, pelvic inflammation, paratrophitis;
3, cholangitis, cholecystitis, liver abscess; Peritonitis;
4. Secondary infection of burns and surgical wounds; 5. Sepsis; 6. Cerebrospinal meningitis.
Uses of Cefmenoxime.
Cephalosporins broad-spectrum antibiotics, strong activity against gram-negative bacteria, stable against β-lactamase, must be injected. It is clinically used for respiratory tract infection, urinary tract infection, female genital organ infection, biliary tract infection, peritonitis, surgery, gynecology and ent diseases caused by sensitive bacteria.
In vitro study of Cefmenoxime.
Product Methods of Cefmenoxime.
Cefotaxime is used as raw material. The trifluoroacetate of cefotaxime is soluble in 272RNG1-methyl-5-mercapto. The solution of 1h-tetrazole, 555mg sodium bicarbonate, 68mg triethylphenylammonium bromide and 10ml water was reacted in nitrogen atmosphere at 60℃ for 6h. It is cooled and passed through a column containing AmberliteXAD-2, first with water and then unrolled with 2.5% ethanol, to obtain a sodium salt of cefoxime, melting point 174-175 ° C (decomposition).
