Pharmaceutical intermediates Phenylephrine Hydrochloride raw powder

CAS:61-76-7

MF:C9H13NO2.ClH

MW:203.67

EINECS:200-517-3

Specification​: 99% min Phenylephrine Hydrochloride

Sample:Phenylephrine Hydrochloride

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:white

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Phenylephrine Hydrochloride Usage and Synthesis.

Deoxyadrenalin hydrochloride, an organic compound, is an alpha adrenergic receptor agonist, used to prevent and treat spinal anesthesia, general anesthesia, chlorpromazine and other causes of hypotension, also used in supraventricular tachycardia and mydriatic examination.

Uses of Phenylephrine Hydrochloride.

It is used for prolonging local time in surgery, reducing inflammation of nasal mucous congestion, dilating eyes, raising pressure of acute hypotension and cold. Adrenergic drugs. It has a constricting effect on local blood vessels in the body. It is used for prolongation of local anesthesia time in surgical surgery, and reduction of swelling and inflammation of nasal mucosa congestion.

In vitro study of Phenylephrine Hydrochloride.

Phenylephrine causes rapid translocation of PKC-epsilon (EC50=0.9 mm), but the proportion of loss from the soluble stage is smaller than that of ET-1. Phenylephrine induces a dose-dependent increase in contractile force in hyperpermeable cells in pCa7, which is reversible after the addition of phentolamine. Phenylephrine also protects cardiomyocytes from hypoxia and serum deprivation treatment. Phenylephrine prevents the down-regulation of Bcl-2 and Bcl-X mRNA/ protein and induces hypertrophic growth. Phenylephrine-mediated protection is inhibited by the phosphatidylinositol 3-kinase (PI3-kinase) inhibitor wortmannin and mimics the caspase 9 peptide inhibitor LEHD-FMK.

Product Method of Bulk Phenylephrine Hydrochloride.

M-hydroxyacetone was benzoylated, brominated, aminated, hydrolyzed and catalyzed to obtain m-hydroxy-α-methylaminomethyl benzyl alcohol (racemic), which was then separated by D-tartaric acid to obtain L-free base. The free alkali was suspended in anhydrous ethanol, hydrogen chloride-ethanol solution was added to pH=4, dissolved by heating, decolorized and filtered by activated carbon, anhydrous ether was added to the filtrate, and crystallization was precipitated by freezing. Leach, crystallize, wash with a small amount of acetone, dry, to obtain phenylephrine hydrochloride