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  • Tenofovir Disoproxil Fumarate Raw Material Valsartan Powder

    • Tenofovir Disoproxil Fumarate Raw Material Valsartan Powder
    • Tenofovir Disoproxil Fumarate Raw Material Valsartan Powder
    • Tenofovir Disoproxil Fumarate Raw Material Valsartan Powder storehouse
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    • Tenofovir Disoproxil Fumarate Raw Material Valsartan Powder quality testing
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    Product Overview:

    Factory Supply Tenofovir Disoproxil Fumarate Powder Purity 99% Tenofovir Disoproxil Fumarate Powder, Manufacturer of Tenofovir Disoproxil Fumarate Raw Material.Tenofovir Disoproxil Fumarate Powder is a nucleotide antiviral for the treatment of human immunodeficiency virus .

    Tenofovir Disoproxil Fumarate Raw Material Valsartan Powder Attributes

    Tenofovir Disoproxil Fumarate Raw Material Powder

    CAS: 202138-50-9

    MF: C23H34N5O14P

    Tenofovir disoproxil fumarate

    MW: 635.52

    EINECS: 687-766-5

    Specification​: 99% min Tenofovir Disoproxil Fumarate

    Sample: Tenofovir Disoproxil Fumarate Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance: White Powder

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Tenofovir Disoproxil Fumarate Raw Material Valsartan Powder Details

    Tenofovir Disoproxil Fumarate Raw Materials Usage and Synthesis

    Factory Supply Tenofovir Disoproxil Fumarate Powder Purity 99% Tenofovir Disoproxil Fumarate Powder, Manufacturer of Tenofovir Disoproxil Fumarate Raw Material.Tenofovir Disoproxil Fumarate Powder is a nucleotide antiviral for the treatment of human immunodeficiency virus .

    Tenofovir Disoproxil Fumarate Powder

    Uses and functions of Tenofovir Disoproxil Fumarate Powder

    Tenofovir disoproxil fumarate (TDF), a nucleotide reverse transcriptase inhibitor, is an orally available open-cyclic nucleotide phosphate pre-drug that is rapidly converted to tenofovir for efficacy after oral absorption. TDF is now the recommended first-line anti-HIV drug with the highest sales due to its high bioavailability, precise efficacy and good tolerability.

    Patent literature reported the synthetic method of tenofovir disoproxil fumarate, but there are some intermediates with many impurities, low optical purity, difficult operation, low yield, unqualified fumaric acid content and unsuitable for industrial production.

    Tenofovir Disoproxil Fumarate Raw Powder

    Pharmacological Effects of Tenofovir Disoproxil Fumarate Raw Powder

    Tenofovir ester is tenofovir diisopropoxymethyl fenvalerate, the ester precursor of tenofovir, an acyclic adenosine 5'-monophosphate analogue .

    It has a broad-spectrum antiviral effect, inhibiting HIV-1 and HIV-2 reverse transcriptase and HBV polymerase, thus inhibiting viral replication.

    Tenofovir Disoproxil Fumarate Powder

    After oral administration, TDF is hydrolysed to tenofovir, which is phosphorylated by cellular kinases into the pharmacologically active metabolite tenofovir diphosphate, which competes with 5'-triphosphate deoxyadenylate and participates in the synthesis of viral DNA, and enters the viral DNA and inhibits viral replication due to the blockage of DNA elongation by the lack of 3'-OH.

    Production method of Raw Tenofovir Disoproxil Fumarate Powder

    Tenofovir disoproxil fumarate is indicated for use in adult patients with CHB who have evidence of viral replication and persistent elevation of serum aminotransferases (ALT or AST) or evidence of active liver disease.

    This includes adult patients with HBeAg-positive or HBeAg-negative compensated CHB.

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