Paracetamol Nebivolol HCL Raw Materials Powder

CAS:169293-50-9

MF: C22H26ClF2NO4

MW: 441.9

EINECS:200-258-5

Specification​: 99% min Nebivolol HCL Powder

Sample: Nebivolol HCL Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Nebivolol HCL Powder Usage and Synthesis.

Yin Sha, Wei Zehu, Zhang Fei et al. studied the protective effect of nebivolol on asymmetric dimethylarginine-induced injury to human umbilical vein endothelial cells by nebivolol, and concluded that nebivolol protects against ADMA-induced injury to HUVECs.

Uses and functions of Nebivolol HCL.

Nebivolol HCL is used in the treatment of hypertension, angina pectoris, myocardial infarction, arrhythmia, congestive heart failure.

Nebivolol HCL is a selective β1-adrenoceptor antagonist with vasodilatory activity and no endogenous sensorineural activity. Used in the treatment of mild to moderate hypertension, angina pectoris and congestive heart failure.

Pharmacological Effects of Nebivolol HCL Raw Materials.

Nebivolol is a long-acting cardioselective adrenergic β1-receptor blocking agent with β1-receptor blocking and related antihypertensive activity, which in therapeutic doses shows enhancement of left ventricular function and reduction of peripheral vascular resistance.

Production method of Nebivolol HCL Raw Powder.

Oral administration of nebivolol results in peak blood concentrations in 0.5-2 hours, with a bioavailability of 12%-96% and no significant effect of food on absorption. The protein binding of Nebivolol is about 98%. The drug is metabolised in the liver by the action of P450 and CYP2D6, and the metabolites are inactive hydroxylated metabolites, nebivolol glucuronide and glucuronide hydroxylated metabolites. The prototype compound has a t1/2 of 10 hours and 48% is excreted via the intestine.